This work presents an investigation of the self-focusing of a high-power laser beam having cosh Gaussian intensity profile in a collissionless plasma under weak relativistic-ponderomotove (RP) and only relativistic regimes and its effect on the excitation of electron plasma wave (EPW), and particle acceleration process. Nonlinear differential equations have been set up for the beam width and intensity of cosh Gaussian laser beam (CGLB) and EPW using the Wentzel-Kramers-Brillouin and paraxial-ray approximations as well as fluid equations. The numerical results are presented for different values of decentered parameter ‘b’ and intensity parameter ‘a’ of CGLB. Strong self-focusing is observed in RP regime as compared with only relativistic nonlinearity. Numerical analysis shows that these parameters play crucial role on the self-focusing of the CGLB and the excitation of EPW. It is also found that the intensity/amplitude of EPW increases with b and a. Further, nonlinear coupling between the CGLB and EPW leads to the acceleration of electrons. The intensity of EPW and energy gain by electrons is significantly affected by including the ponderomotive nonlinearity. The energy of the accelerated electrons is increased by increasing the value of ‘b’. The results are presented for typical laser and plasma parameters.