In the absence of government safety regulation in the field of nanotechnology, ISO standards are being used as the basis for establishing technical and management guidelines at an international level. There are more than 50 current ISO standards on nanotechnology. Some of these relate to the working environment and occupational risk management. In Latin America, entities that are members of ISO are enunciating national versions of the international standards. In this article, this context is analysed critically, starting from the Mexican standard on occupational risk management in the working environment. Even though risk management standards may guarantee better and safer working conditions, in the field of nanotechnology, they simultaneously unlock detrimental implications for workers and society. Reliance on such private and voluntary forms of industry self-regulation is identified as a by-product of global neoliberalism.