A multiple-vehicles time-coordination guidance technique based on deep learning is suggested to address the cooperative guiding problem of hypersonic gliding vehicle entry phase. A dual-parameter bank angle profile is used in longitudinal guiding to meet the requirements of time coordination. A vehicle trajectory database is constructed along with a deep neural network (DNN) structure devised to fulfill the error criteria, and a trained network is used to replace the conventional prediction approach. Moreover, an extended Kalman filter is constructed to detect changes in aerodynamic parameters in real time, and the aerodynamic parameters are fed into a DNN. The lateral guiding employs a logic for reversing the sign of bank angle, which is based on the segmented heading angle error corridor. The final simulation results demonstrate that the built DNN is capable of addressing the cooperative guiding requirements. The algorithm is highly accurate in terms of guiding, has a fast response time, and does not need inter-munition communication, and it is capable of solving guidance orders that satisfy flight requirements even when aerodynamic parameter disruptions occur.