Herbicide-resistant cultivars account for over 90% of the canola grown in western Canada and cultivars resistant to glyphosate dominate the market. Field experiments were conducted at three locations in Alberta to compare the glyphosate system with more traditional herbicide regimes. Glyphosate applied before seeding in spring resulted in better weed control, lower dockage, and higher canola yield and net return than 2,4-D applied in the fall. Glyphosate applied once (two- to four-leaf canola) or twice (two- to four-leaf followed by five- to six-leaf canola) in-crop provided similar weed control, dockage, and canola yield as ethalfluralin applied PRE in the fall followed by an in-crop mixture of sethoxydim, ethametsulfuron, and clopyralid; and superior weed control and canola yield and lower dockage than ethalfluralin alone or an in-crop mixture of sethoxydim and ethametsulfuron. The in-crop glyphosate applications resulted in higher net revenues than the other treatments. There was little or no advantage to applying glyphosate twice compared with once in-crop. The amount of active ingredient entering the environment varied with the herbicide regime but was lower with the glyphosate system than with most of the traditional regimes, especially when glyphosate was applied only once in-crop.