This chapter examines the configurations of Latin Americanism enacted by the renowned and enduring cultural organism Casa de las Américas, established shortly after the Cuban Revolution’s triumph in 1959. The chapter provides a detailed overview of the diverse thematics and functions in the purview of Casa, which positioned itself as a beacon for José Martí’s hemispheric vision of the Americas, encompassing the Caribbean, Mexico, Central America, and South America. The chapter examines Casa’s relationship to emancipatory thought in opposition to capitalist and imperialist visions, exploring its role as cultural producer and disseminator, with an emphasis on particular genres such as the testimonio and theater and through the prestigious Casa de las Américas awards for Latin American writers (1960–); a publishing house; theater festivals; the journals Casa de las Américas (1960–) and Conjunto (1964–); the organization of multiple international events focusing on literature, music, theater, and visual arts; and, toward the end of the twentieth century and the beginning of the twenty-first, in new research centers related to cultural studies.