Weed scientists are facing research problems, such as invasive weeds, that may require multidisciplinary approaches to solve. One example is jointed goatgrass, a winter annual grass invading winter wheat fields and not easily managed with conventional control tactics. A national research program was started in 1994 to develop jointed goatgrass management strategies. Involving more than 35 scientists with diverse scientific expertise, this national approach fostered cooperative research projects across 11 states. Research involved entomology, economics, plant breeding, plant physiology, genetics, and weed science, leading to successful management systems for jointed goatgrass. To help other scientists organize regional or national programs, we describe development and performance of the jointed goatgrass program as well as suggest ideas for possible improvement. Pivotal to the success of the program was a Steering Committee, whose role was to establish research priorities and coordinate research across the western United States.