Elephant ranges in Asia overlap with human-use areas, leading to frequent and often negative two-way interactions, a fraction of which result in human fatalities. Minimizing such negative interactions rests on gaining a mechanistic understanding of their patterns and underlying processes. In Chhattisgarh (India), a rewilding population of 250–300 elephants that have recently expanded their range from neighbouring states through dispersal has been causing annual losses of >60 human lives. Using logistic regression models, we examined the influences of eight plausible predictors of the occurrence of elephant-related human fatality incidents. We found that 70% of incidents occurred in areas with high-intensity habitat use by elephants; the other 30% were in areas of intermediate and sporadic elephant habitat use. The probability of human fatalities was high along the roads connecting settlements and in areas with frequent house break-ins by elephants, and this probability was also affected by the spatial geometry of forest patches. Immediate practical options to minimize fatal interactions include community-based early-warning systems and the use of portable barriers around settlements. Judicious landscape-level land-use planning aimed at maintaining the resilience of remnant intact elephant habitats will be critical to preventing the dispersal of elephants into suboptimal habitats, which can create complex conflict situations.