Three clay materials (codded MY3, KG and KK) from western Cameroon were selected and investigated for the production of refractory bricks. Samples MY3 and KG are kaolinite-rich materials, having clay mineral contents of 88% and 72%, respectively, whereas KK is a sand-rich material with a total clay content of 44%. Chamottes were prepared using each clay, and the ground chamottes were later used in the refractory formulation, with each raw clay used as a binding phase. After firing, the X-ray diffraction analyses of all of the refractory bricks indicated the same mineral assemblage made of quartz, cristobalite and mullite. The cristobalite is due to high-temperature conversion of quartz, whereas the mullite is due to clay mineral conversion. The evaluation of the linear shrinkage, physical properties (including bulk density and open porosity) and mechanical testing through refractoriness under load and compressive strength indicates that all of these clays could be used as raw materials for standard clay refractory materials. These results stand as a proof for the potential for these locally available materials to be used as raw materials for refractories that could be locally produced to reduce the cost of access to refractory raw materials faced by industries located in Cameroon.