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1 results

  • New proposal to revise the classification for squamous cell carcinoma of the external auditory canal and middle ear

  • H Shinomiya, N Uehara, T Fujita, K Yoshida, Y Imamura, M Teshima, H Kimura, D Miyawaki, A Kakigi, N Kiyota, N Otsuki, R Sasaki, E Kohmura, K Nibu
  • Journal:
    The Journal of Laryngology & Otology / Volume 135 / Issue 4 / April 2021
    Published online by Cambridge University Press:
    31 March 2021, pp. 297-303
    Print publication:
    April 2021
  • Background

    The prognosis of patients with advanced squamous cell carcinoma of the external auditory canal and middle ear has been improved by advances in skull base surgery and multidrug chemoradiotherapy during the last two decades.

    Methods

    Ninety-five patients with squamous cell carcinoma of the external auditory canal and middle ear who were treated between 1998 and 2017 were enrolled. The number of patients with tumour stages T1, T2, T3 and T4 was 15, 22, 24 and 34, respectively. Oncological outcomes and prognostic factors were retrospectively investigated.

    Results

    Among patients with T4 disease, invasion of the brain (p = 0.024), carotid artery (p = 0.049) and/or jugular vein (p = 0.040) were significant predictors of poor prognosis. The five-year overall survival rate of patients with at least one of these factors (T4b) was significantly lower than that of patients without these factors (T4a) (25.5 vs 65.5 per cent, p = 0.049).

    Conclusion

    It is proposed that stage T4 be subclassified into T4a and T4b according to the prognostic factors.