This 2021 ASA Presidential Lecture combines sociopolitical history with personal reflections on Black Harlem during African decolonization. It begins at the turn of the twentieth century and traces Harlem’s transformation into an international center of pan-Africanist activism and cultural production. Brown explores solidarities that grew as Harlem politicians, grassroots leaders, and residents encountered political exiles and cultural leaders from the continent, the diaspora, and aligned political movements worldwide. These alliances and modes of protest facilitated a hardening of militant activist traditions and cultural cohesion that shaped an anti-imperialist pan-African movement and ultimately a multinational Black political movement in the 1960’s to 1990s.