In this work, a compact, wideband, circularly polarized wearable antenna is proposed using asymmetric coplanar strip feeding for wireless health monitor applications in the ISM frequency band. The proposed antenna consists of a composite right/left transmission line (CRLH TL) inspired structure to achieve compactness and a rectangular ring slot is created in the metallic ground to enhance the CP radiation of the antenna. A 5 × 5 artificial magnetic conductor unit cell-based metasurface is designed which is operating at 2.4 GHz as a ground plane for the CRLH-based CP antenna. Implementation of AMC-based metasurface as a ground plane results in enhancement of radiation characteristics of CRLH TL antenna. The proposed antenna has a small footprint of 50 × 50 mm2 with measured impedance bandwidth of 2.3–3.2 GHz. The 3 dB axial ratio bandwidth of the proposed antenna is 2.36–2.78 GHz with peak gain of 5.89 dBi. Simulation and experimental results show that proposed AMC-based antenna is robust in terms of structural deformation. Further, to validate the performance of the antenna for biomedical applications, we have simulated the proposed antenna with human phantom model. The proposed antenna exhibits stable scattering and radiation characteristics with the phantom body environment and due to the inclusion of AMC structure, the proposed design satisfies maximum specific absorption rate value given as per the IEEE standard safety guidelines.