The uses of a prebiotic to replace antibiotic growth promoters, mycotoxin and cholesterol binders in broiler diets have been commonly practiced over the last three decades. Many products have appeared commercially to replace antibiotic growth promoters and to tackle the problems of mycotoxins contamination. Mannose-based carbohydrates, particularly mannan-oligosaccharides from yeast, appear to have properties of coping with the mycotoxin related problems. Over the last three years, studies on the use of copra-mannan (CM) in this respect have produced promising results. CM has been found to effectively improve bird performance. When the birds were challenged against Escherichia coli, the supplementation of the feed with CMs was able to maintain growth performance of birds to the same level as the growth of birds fed commercial mannan-oligosaccharides or antibiotics. Contamination of feed with 0.3 ppm aflatoxin B1 reduced feed digestibility, but not when the feed was mixed with CM. The supplementation of the diet with CMs protects the birds from wet droppings when the birds were challenged by either Escherichia coli or aflatoxin contamination. Since there is a conflicting information about using mannans in the diet, particularly between using legume mannans as an antinutrient and yeast mannans as a pronutrient, this paper reviews the potential use of CMs for the purposes of promoting growth and improving health status of broiler chickens.