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c-jun

Acta geneticae medicae et gemellologiae: twin research (1)

International Soc for Twin Studies (1)

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Immunohistochemical Analysis of c-Fos and c-Jun in Retinoblastoma
F. Faraldi, A. Calzolari, M. Forni, F.L. Chiarelli Mincione, G. Alfieri
Journal:

Acta geneticae medicae et gemellologiae: twin research / Volume 45 / Issue 1-2 / April 1996

Published online by Cambridge University Press:

01 August 2014, pp. 289-291

Print publication:

April 1996
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The c-fos promoter is negatively regulated by the retinoblastoma (Rb)-suceptibility-gene- encoded protein as well as by other genes involved in the control of transcription, cell cycle regulation and neoplastic transformation. We have examined by immunohistochemistry the c-Fos and c-Jun proteins in five cases of retinoblastoma in order to evaluate eventual alterations in their expression in vivo, possibly related to a gene mutation or to loss of Rb negative control.