This article documents and interprets the Spanish trade in American cotton which developed between the 1740s and 1790s. Following an analysis of the historiography concerning the trade, it provides data on the quantities imported, the state, ginned or unginned, in which it was imported, its origins in the American empire, the shipping arrangements made for its transport, the charges for its freight and the prices which were paid for it in Spain. It shows the growth of the trade to be related to growing demand for raw cotton during the early stages of Catalan industrialization, the meeting of which was facilitated by the reforms introduced in the Hispanic colonial system.