Based on bankruptcy and inheritance files and on population and business registers from Ruanda-Urundi, this paper reconstructs the local and long-distance professional and affective relations of Indian and Arab merchants operating in and around Bujumbura in the two decades before and after the Great Depression (1920s–1930s). The story complements the historiography on Asian diasporas in East Africa by going beyond the Indian Ocean coast, beyond the precolonial period, and beyond British-governed territories. Looking at different spheres of life and scales of action and assessing both commercial success and failure, this article makes a case for the importance of local dynamics and the relevance of cross-community relations within the relatively small foreign trade sector in the region. The reliance on “home” and kin remained important as mutual insurance at times of arrival and misfortune: firmly established first-comers assisted their relatives upon arrival, while at times of bankruptcy, death, or old age, long-distance family ties proved vital as well. However, facing discriminatory colonial measures, the Arab and Indian merchants were gradually relegated to the role of intermediaries in long-distance trade. Consequently, day-to-day business relations were increasingly a local, cross-community, and above all, precarious affair.