To test the assumption that monochorionic twins are monozygotic, cord bloods from 12 sets of monochorionic twins were tested for a total of 16 red cell antigens. Discrepancies were noted among the minor blood groups in 3 of the 12 sets. The result of this pilot study strengthens the contention of others who have previously questioned the general acceptance that monochorionicity and monozygosity are synonymous.