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1 results

  • Stridor: unusual presentation of multiple myeloma

  • David Sinclair, Adel Resouly, Anne Spedding
  • Journal:
    The Journal of Laryngology & Otology / Volume 117 / Issue 10 / October 2003
    Published online by Cambridge University Press:
    08 March 2006, pp. 829-831
    Print publication:
    October 2003

  • We present a patient with multiple myeloma whose only presenting symptom was stridor caused by a subglottic stenosis. Biopsy suggested the presence of amyloid which prompted immunological investigations that showed hypogammaglobulinaemia and the presence of Bence Jones proteinuria at 0.93 g/24 hours. Further investigation demonstrated a 15 per cent plasma cell infiltrate into the bone marrow and a lytic lesion in the mid-shaft of the right femur. Chemotherapy and localized radiotherapy were commenced. This is a most unusual presentation of multiple myeloma and shows that immunoglobulin profiles should be properly investigated in such cases.