This manuscript presents a 50 Ω microstrip-fed quad-element high isolated ultra-wideband (UWB) multiple-input multiple-output (MIMO) antenna with band-notched characteristics. The overall area of the proposed structure is 0.33λo × 0.33λo mm2 (where λo depicts the free space wavelength corresponding to the lower cutoff frequency, i.e. 2.54 GHz), etched on an FR-4 substrate of thickness 0.8 mm. The top layer has four semicircular disc-shaped radiating elements that are identical and orthogonal to obtain better inter-element isolation and compactness. A reverse two-shaped slot is etched onto the radiating patches to attain a band-rejection capability. Moreover, a decoupling structure is also placed at the top layer to suppress the unwanted surface waves. The bottom layer consists of a ground plane, which is further modified with quasi-self complementary and meandered line slots. A rectangular slot is also etched below the feed line to better match the impedance near the lower cutoff frequencies. The simulated reflection coefficients (S11) of the proposed antenna are less than −10 dB over 2.54 to 10.74 GHz frequencies except at 3.37 to 4.15 GHz (WiMAX/C band), and the simulated inter-port isolation (S21) is greater than −15 dB over the entire UWB range of frequencies (3.1 to 10.6 GHz). Also, the measured S-parameter results well agreed with the simulated ones. Furthermore, the simulation study of the 20-element UWB-MIMO antenna is also investigated using the proposed quad-element structure.