Indigenous scholars and leaders have long been interested in reducing the role of the Canadian state in their political, economic, and social lives. This paper explores the extent to which digital currencies, such as Bitcoin or MazaCoin, might be used to facilitate Indigenous self-determination, political autonomy, and economic prosperity. Based on our review of the literature, we argue that cryptocurrencies demonstrate some potential for advancing these goals but that there are a number of potential roadblocks as well. Future research should investigate how Indigenous communities might use digital currencies and other related technologies to further their political, economic, and social goals.