The essay looks at the challenges Australian Indigenous materialisms make to the Western concept of human and its relation to the inhuman, and it does this through reading the novels of Waanyi writer, critic, and activist Alexis Wright. In the Australian context, a highly productive knot is being tied between post-humanism and postcolonialism, such that the binary of “culture” and “nature” is understood in relation to another binary couple that sits snugly within “culture” and “nature,” and that is “colonizer” and “native.” The place of Indigenous-signed literary texts in critiques of Western materialisms cannot be underestimated. It is through the arts that most encounters between Indigenous and settler Australians take place. How non-Indigenous readers might approach these literary texts is a key ethical question with implications for new materialist and post-humanist projects.