This chapter explores why Lisa Lowe's essay on Heterogeneity, Hybridity, Multiplicity: Asian American Differences, from her book Immigrant Acts: On Asian American Cultural Politics, and its related focus on clearing a space for diaspora and transnationalism, was so instrumental in creating a paradigmatic shift in the ways in which literary scholars approached questions of inclusions and exclusion within Asian American studies. It explores why this essay struck such a responsive chord among Asian Americanist scholars and writers. While the conceptual framework that Lowe advanced in heterogeneity, hybridity and multiplicity has been foundational within Asian American literary studies, it is also notable for ushering in new forms of critique. In an increasingly neoliberal moment, there is an ever-likely danger of further homogenization of the Asian subject. Lowe's essay serves as an important reminder of the need for literary critique to think through the structuring differences of heterogeneity, hybridity, and multiplicity.