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1 results

  • Rapid thyrotoxicosis in anaplastic thyroid carcinoma

  • J S Phillips, D R Pledger, A W Hilger
  • Journal:
    The Journal of Laryngology & Otology / Volume 121 / Issue 7 / July 2007
    Published online by Cambridge University Press:
    11 December 2006, pp. 695-697
    Print publication:
    July 2007

  • We present the case of a 71-year-old man with anaplastic thyroid cancer. On presentation, his thyroid function was normal, but he subsequently developed sudden, rapid thyrotoxicosis. Thyrotoxicosis in anaplastic thyroid carcinoma is very rare, but in all previously reported cases the patient was thyrotoxic at presentation. Our case is unusual as our patient presented euthyroid, and thyrotoxicosis developed subsequently. We challenge current ideas regarding the biochemical pathophysiology of rapid thyrotoxicosis in anaplastic thyroid carcinoma and provide an alternative explanation.