This study presents a novel configuration of a cuboidal quad-port ultra-wideband multiple-input and multiple-output antenna with WLAN rejection characteristics. The designed antenna consists of four F-shaped elements backed by a partial ground plane. A 50 Ω microstrip line is used to feed the proposed structure. The geometry of the suggested antenna exhibits an overall size of 23 × 23 × 19 mm3, and the antenna produces an operational bandwidth of 7.6 GHz (3.1–10.7 GHz). The notched band characteristic at 5.4 GHz is accomplished by loading a pair of spiral electromagnetic bandgap structures over the ground plane. Besides this, other diversity features such as envelope correlation coefficient, and diversity gain are also evaluated. Furthermore, the proposed antenna system provides an isolation of −15 dB without using any decoupling structure. Therefore, to validate the reported design, a prototype is fabricated and characterized. The overall simulated performance is observed in very close agreement with it's measured counterpart.