Several important cases of vector bundles with extra structure (such as Higgs bundles and triples) may be regarded as examples of twisted representations of a finite quiver in the category of sheaves of modules on a variety/manifold/ringed space. It is shown that the category of such representations is an abelian category with enough injectives by the construction of an explicit injective resolution. Using this explicit resolution, a long exact sequence is found that computes the Ext groups in this new category in terms of the Ext groups in the old category. The quiver formulation is directly reflected in the form of the long exact sequence. It is also shown that under suitable circumstances, the Ext groups are isomorphic to certain hypercohomology groups.