Collaboration between local governments and businesses for poverty reduction has not yet been fully explored in China. Based on an in-depth investigation of two counties during the Targeted Poverty Alleviation campaign, this study proposes a multilayered and relational approach to understanding how different levels of officials collaborate with business to reduce poverty. Elite bureaucrats at the county and township levels prefer a growth-oriented strategy for attracting large-scale enterprises to make investment. Their coalition with businesses has created profits and employment but also hindered authentic participation of small- and medium-sized businesses and villagers in their selected villages. In contrast, in villages that were not prioritized by elite bureaucrats, local officials could utilize their discretion and indigenous resources to exploit development opportunities and support small- and medium-sized businesses to reach poor villagers. This study unpacks China's multilevel system to understand the various forms of government–business collaboration and their implications for rural poverty reduction.