Radicalization in prison is a well-developed field of research that, particularly in the aftermath of 11 September 2001, has involved academics and practitioners in the attempt to highlight possible push and pull factors and dynamics, as well as useful strategies for preventing and countering extremism inside the facilities. Like every subject of great interest, it has given rise to numerous theories about the possible approaches to radical violence, some even at odds with each other. However, there is almost unanimous agreement that isolation from external society and the inadequate management of the right to profess one’s religious faith within prisons may be elements that increase the risk of intramural radicalization. In Italy, the COVID-19 pandemic interfered heavily not only in the lives of people belonging to free society but also – and perhaps even more – in the lives of prisoners, resulting in the total isolation of prison facilities from the outside community. The dramatic efforts to protect public health have effectively eclipsed every other right, including – for prisoners – practising one’s faith with the guidance of authorized religious leaders. The present article explores how and why these anti-virus changes in the management of the Italian penitentiary could have influenced the risk of intramural radicalization.