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1 results

  • Cerebral perfusion correlates of depressed mood

  • Klaus P. Ebmeier, Jonathan T. O. Cavanagh, Anthony P. R. Moffoot, Michael F. Glabus, Ronan E. O'Carroll, Guy M. Goodwin
  • Journal:
    The British Journal of Psychiatry / Volume 170 / Issue 1 / January 1997
    Published online by Cambridge University Press:
    02 January 2018, pp. 77-81
    Print publication:
    January 1997
  • Background

    The spontaneous diurnal variation of mood and other symptoms provides a substrate for the examination of the relationship between symptoms and regional brain activation in depression.

    Method

    Twenty unipolar depressed patients with diurnal variation of mood were examined at 8 a.m. and 8 p.m. with neuropsychological measures, clinical ratings and single photon emission tomography (SPET). Brain perfusion maps were spatially transformed into standard stereotactic space and compared pixel-by-pixel. A parametric (correlational) analysis was used to examine the relationship between symptom severity and brain perfusion, both between and within subjects.

    Results

    Global depression severity and an independent ‘vital’ depression factor were associated in subjects with increased perfusion in cingulate and other paralimbic areas. In addition there was a probable association between an increase in an anxious-depression factor and reduced frontal neocortical perfusion.

    Conclusions

    Depressive symptom changes are associated with metabolic changes in the cingulate gyrus and associated paralimbic structures.