Introduction/Objectives:
Aseptic meningitis (AM), with or without other drug-induced neurological disorders, has been the subject of several reviews.
Participants, Materials/Methods:
We report clinically rare and serious adverse reactions that occurred after the co-administration of Ibuprofen and Ciprofloxain: completely reversible aseptic meningitis and irreversible bilateral sensorineural hearing loss, tinnitus, and vestibulopathy.
Results:
Recurrent urinary inflammations treated with antibiotics, classic migraine, and allergy to trimethoprim-sulfamethoxazole and chromium were favourable predisposing factors for the adverse event in this patient. A close chronological relation between administration of drugs (especially Ibuprofen) and adverse reactions was noted. No evidence of infection and/or autoimmune disease was found.
Conclusions:
The mechanism of these serious events may be explained as a hypersensitive reaction affecting the meninges and, partially, cochlea.
