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OC38: Introduction of plasma vitamin C and Ferric Reducing Antioxidant Power into a combined biomarker with plasma carotenoids increases the association with fruit and vegetable intake

Published online by Cambridge University Press:  15 April 2015

Y. Jin ,
M. H. Gordon ,
D. Alimbetov ,
M. F.-F. Chong ,
T. W. George ,
J. P. E. Spencer ,
O. B. Kennedy ,
K. M. Tuohy ,
A.-M. Minihane  and
J. A. Lovegrove
...Show all authors
Y. Jin
Affiliation:
Department of Health Sciences, Liverpool Hope University, Liverpool L16 9JD, UK Hugh Sinclair Unit of Human Nutrition Institute of Cardiovascular and Metabolic Research, Department of Food and Nutritional Sciences, the University of Reading, Whiteknights, PO Box 226, Reading RG6 6AP, UK
M. H. Gordon
Affiliation:
Hugh Sinclair Unit of Human Nutrition Institute of Cardiovascular and Metabolic Research, Department of Food and Nutritional Sciences, the University of Reading, Whiteknights, PO Box 226, Reading RG6 6AP, UK
D. Alimbetov
Affiliation:
Hugh Sinclair Unit of Human Nutrition Institute of Cardiovascular and Metabolic Research, Department of Food and Nutritional Sciences, the University of Reading, Whiteknights, PO Box 226, Reading RG6 6AP, UK Department of Bioengineering, Cell Technologies and Cell Therapy, Centre for Life Sciences, Nazarbayev University, 53 Kabanbay Batyr Ave., Astana, 010000, Kazakhstan
M. F.-F. Chong
Affiliation:
Hugh Sinclair Unit of Human Nutrition Institute of Cardiovascular and Metabolic Research, Department of Food and Nutritional Sciences, the University of Reading, Whiteknights, PO Box 226, Reading RG6 6AP, UK Clinical Nutrition Research Centre, Singapore Institute for Clinical Sciences, A*STAR, 14 Medical Drive, #07–02, Singapore 117599
T. W. George
Affiliation:
Hugh Sinclair Unit of Human Nutrition Institute of Cardiovascular and Metabolic Research, Department of Food and Nutritional Sciences, the University of Reading, Whiteknights, PO Box 226, Reading RG6 6AP, UK Ellison Building, Department of Applied Sciences, Faculty of Health and Life Sciences, Northumbria University, Newcastle Upon Tyne NE1 8ST, UK
J. P. E. Spencer
Affiliation:
Hugh Sinclair Unit of Human Nutrition Institute of Cardiovascular and Metabolic Research, Department of Food and Nutritional Sciences, the University of Reading, Whiteknights, PO Box 226, Reading RG6 6AP, UK
O. B. Kennedy
Affiliation:
Hugh Sinclair Unit of Human Nutrition
K. M. Tuohy
Affiliation:
Hugh Sinclair Unit of Human Nutrition Research and Innovation Centre, Fondazione Edmund Mach, via Mach 1, 38010 San Michele all'Adige, Trento, Italy
A.-M. Minihane
Affiliation:
Hugh Sinclair Unit of Human Nutrition Norwich Medical School, University of East Anglia, Norwich NR4 7TJ, UK
J. A. Lovegrove
Affiliation:
Hugh Sinclair Unit of Human Nutrition Institute of Cardiovascular and Metabolic Research, Department of Food and Nutritional Sciences, the University of Reading, Whiteknights, PO Box 226, Reading RG6 6AP, UK
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Abstract

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Proceedings of the Nutrition Society , Volume 74 , Issue OCE1: Summer Meeting, 14–17 July 2014, Carbohydrates in health: friends or foes , 2015 , E38
Copyright
Copyright © The Authors 2015 

Monitoring of fruit and vegetable (F&V) intake is fraught with difficulties. Available dietary assessment methods are associated with considerable error and use of biomarkers offers an attractive alternative(Reference Pollard, Wild and White1). Few studies to date have examined the use of plasma biomarkers to monitor or predict F&V intake of volunteers consuming a wide range of intake from both habitual F&V and manipulated diets. This study combined plasma vitamin C and carotenoid concentrations with Ferric Reducing Antioxidant Power (FRAP) as an integrated biomarker of F&V intake and compared the predictive powers of each single and integrated biomarker for F&V intake. Data from a randomized, controlled, dietary intervention study (FLAVURS) (n = 154) in which the test groups had observed sequential increases of 2·3, 3·2 and 4·2 portions of F&V every 6-wk across an 18-wk period was used in this study. A modified integrated plasma biomarker was devised which included plasma vitamin C, total carotenoids and FRAP values, and this gave a better correlation with F&V intake (r = 0·516, P < 0·001) than the individual biomarkers (r = 0·332, P < 0·001; r = 0·417, P < 0·001; r = 0·136, P = 0·099 respectively). Inclusion of urinary potassium concentration did not significantly improve the correlation. The modified integrated plasma biomarker more accurately predicted F&V intake to within 2 portions of the actual intake in 54·3 ± 4·9% of the population compared with plasma carotenoid concentration (48·3 ± 11·3%), although this difference did not reach statistical significance (P > 0·05). Either plasma carotenoid concentration or the integrated biomarker could be used to distinguish high and low F&V consumers.

The FLAVURS study was funded by the Food Standards Agency and conducted at the University of Reading.

References

1.Pollard, J, Wild, CP, White, KL et al. (2003) Eur J Clin Nutr 57, 988–998.Google Scholar