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Authors' reply

Published online by Cambridge University Press:  02 January 2018

Ruoling Chen
Affiliation:
Department of Epidemiology and Public Health, University College London, 1–19 Torrington Place, London WC1E 6BT, UK. Email: [email protected]
Zhi Hu
Affiliation:
School of Health Administration, Anhui Medical University, China
Li Wei
Affiliation:
Medicines Monitoring Unit, Ninewells Hospital and Medical School, University of Dundee, UK
Xia Qin
Affiliation:
School of Health Administration, Anhui Medical University, China
Cherie McCracken
Affiliation:
Division of Psychiatry, University of Liverpool, UK
John R. Copeland
Affiliation:
Division of Psychiatry, University of Liverpool, UK
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Abstract

Type
Columns
Copyright
Copyright © Royal College of Psychiatrists, 2009 

We appreciate Dr Singh's interest in our recent article, Reference Chen, Hu, Wei, Qin, McCracken and Copeland1 but we believe Dr Singh misunderstands our findings. First, in our two cohort studies we did not say that there was an existing dose–response association between the severity of depression and the risk of dementia. On the contrary, our data have suggested that only the most severe syndromes and cases of depression are a risk factor for developing dementia. Second, we put the two cohort studies from China and the UK in one paper because both of them used the same Geriatric Mental State–Automated Geriatric Examination for Computer Assisted Taxonomy method for the assessment and diagnosis of depression and dementia (in syndromes and cases), which would provide equivalent data between the centres for the proposed analysis. Although there are significant differences in ethnicity, social demographic background and disease patterns between the two populations, the results are consistent, suggesting our findings are robust. Third, it is known that in many Eastern countries elderly people are looked after at home, rather than in nursing homes. Traditionally, the Chinese family would take care of their frail and sick elderly. Reference Chiu and Zhang2,Reference Chen, Wei, Hu, Qin, Copeland and Hemingway3 Both studies aimed to enumerate all the cases of dementia wherever they were found. Thus, we believe the composition of the Chinese cohort is similar to that of the UK cohort in terms of its predisposition to physical and depressive comorbidities. Fourth, we have mentioned in the paper that the small number of dementia cases in the Chinese cohort is one of the study limitations. Nevertheless, the UK cohort data support the Chinese findings. Therefore, we believe the findings are quite reliable. Fifth, in our sensitivity analysis excluding all participants with baseline organic syndrome at Level ⩾3, we did not say that the risk of dementia was associated with depression at Levels 1, 2 and 3 because their HRs are around 1.00 and not significant, but our data have further shown that only the most severe depression (i.e. Level ⩾4) is a risk factor for developing dementia.

References

1 Chen, R, Hu, Z, Wei, L, Qin, X, McCracken, C, Copeland, JR. Severity of depression and risk for subsequent dementia: cohort studies in China and the UK. Br J Psychiatry 2008; 193: 373–7.Google Scholar
2 Chiu, HF, Zhang, M. Dementia research in China. Int J Geriatr Psychiatry 2000; 15: 947–53.Google Scholar
3 Chen, R, Wei, L, Hu, Z, Qin, X, Copeland, JR, Hemingway, H. Depression in older people in rural China. Arch Intern Med 2005; 165: 2019–25.Google Scholar
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