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Attenuated Salmonella as live vaccines: prospects for multivalent poultry vaccines

Published online by Cambridge University Press:  23 March 2009

Hugh G. Griffin
Hugh G. Griffin
Affiliation:
Division of Molecular Biology, AFRC Institute for Animal Health, Houghton Laboratory, Houghton, Huntingdon, Cambridgeshire, UK
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Abstract

Live attenuated strains of Salmonella spp. make excellent vaccines against salmonellosis in experimental animals, eliciting a cell-mediated, mucosal and humoral immune response. In addition, new recombinant DNA technology permits the expression in Salmonella strains of protective antigens from unrelated bacterial, viral or parasitic pathogens. Exciting possibilities exist for a single live vaccine which could provide protection against two or more infectious agents. Recently, attenuated strains of the chicken pathogen Salmonella gallinarum have been considered as the basis of a live multivalent poultry vaccine and work is progressing on the expression of coccidial and herpes viral antigens in strains of Salmonella.

Keywords

Salmonellavaccinecoccidiosisinfectious laryngotracheitis virusrecombinant DNAattenuation
Type
Reviews
Information
World's Poultry Science Journal , Volume 47 , Issue 2 , July 1991 , pp. 129 - 140
Copyright
Copyright © Cambridge University Press 1991

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