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The Maudsley Family Study 4. Normal planum temporale asymmetry in familial schizophrenia

A volumetric MRI study

Published online by Cambridge University Press:  03 January 2018

S. Frangou ,
T. Sharma ,
T. Sigmundsson ,
P. Barta ,
G. Pearlson  and
R. M. Murray
S. Frangou*
Affiliation:
Kings College School of Medicine and Dentistry and the Institute of Psychiatry, London
T. Sharma
Affiliation:
Institute of Psychiatry, London
T. Sigmundsson
Affiliation:
Institute of Psychiatry, London
P. Barta
Affiliation:
Department of Psychiatry and Behavioural Sciences, Johns Hopkins University, Baltimore, US
G. Pearlson
Affiliation:
Department of Psychiatry and Behavioural Sciences, Johns Hopkins University, Baltimore, US
R. M. Murray
Affiliation:
Kings College School of Medicine and Dentistry and the Institute of Psychiatry, London
*
Dr S. Frangou, Department of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, London SE5 8AF. Fax: 0171 701 9044
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Abstract

Background

Loss or reversal of the normal asymmetry of the planum temporale (PT) has been reported in schizophrenia, and may be due to aberrations in the gene(s) controlling the development of brain asymmetries. We tested this hypothesis in a sample of schizophrenics and their relatives from families multiply affected with the disorder.

Method

We compared 32 schizophrenics and 55 of their non-schizophrenic first-degree relatives with 39 matched community controls. Volumetric measurements of the cortical volume beneath the PT were obtained using the Cavalieri method from three-dimensionally reconstructed magnetic resonance imaging images.

Results

PT volume asymmetry coefficients from patients and their relatives did not differ significantly from those of the controls. Gender-specific analysis did not reveal any differences.

Conclusions

Abnormalities in PT volume asymmetry are not present in familial schizophrenia, where genetic factors appear to predominate.

Type
Papers
Information
The British Journal of Psychiatry , Volume 170 , Issue 4 , April 1997 , pp. 328 - 333
Copyright
Copyright © 1997 The Royal College of Psychiatrists 

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References

American Psychiatric Association (1987) Diagnostic and Statistical Manual of Mental Disorders (3rd edn, revised) (DSM-III-R). Washington. DC: APA.Google Scholar
Annett, M. (1970) A classification of hand preference by association analysis. British Journal of Psychology, 61, 303–321.CrossRefGoogle ScholarPubMed
Barta, P. E., Petty, R. G., McGilchrist, I., et al (1995) Asymmetry of the planum temporale: methodological considerations and clinical associations. Psychiatry Research, 61, 137–150.CrossRefGoogle ScholarPubMed
Barta, P. E., Petty, R. G., McGilchrist, I., Dhingra, L., RoyalI, R., et al (1997) Improving stereological estimates for the volume of structures identified in 3-dimensional arrays of spatial data. Journal of Neuroscience Methods, in press.CrossRefGoogle Scholar
Barta, P. E., Petty, R. G., McGilchrist, I., Dhingra, L., RoyalI, R., Pearlson, G. D., Brill, L. B. L., et al (1997) Planum temporale asymmetry reversal in schizophrenia: replication and relationship to gray matter changes. American Journal of Psychiatry, in press.Google Scholar
Bartley, A. J., Jones, D. W., Torrey, E. F., et al(1993) Sylvian fissure asymmetries in monozygotic twins: a test of laterality in schizophrenia. Biological Psychiatry, 34, 853–863.CrossRefGoogle ScholarPubMed
Bllder, R. M., Wu, H., Bogerts, B., et al(1994) Absence of regional hemispheric volume asymmetries in first-episode schizophrenia. American Journal of Psychiatry, 151, 1437–1447.Google Scholar
Crow, T. J. (1990) Temporal lobe asymmetries as the key to the etiology of schizophrenia. Schizophrenia Bulletin, 16, 433–443.CrossRefGoogle Scholar
De Lisi, L. E., Hoff, A. L., Neale, C., et al(1994) Asymmetries in the superior temporal lobe in male and female first-episode schizophrenic patients: measures of the planum temporale and superior temporal gyrus by MRI. Schizophrenia Research, 12, 19–28.CrossRefGoogle ScholarPubMed
Endicott, J. & Spitzer, R. L. (1978) A diagnostic interview: the Schedule for Affective Disorders and Schizophrenia. Archives of General Psychiatry, 35, 837–844.CrossRefGoogle ScholarPubMed
Endicott, J. & Spitzer, R. L., Andreasen, N. C. & Spitzer, R. L. (1975) Family History Research Diagnostic Criteria. New York: New York State Psychiatric Institute.Google Scholar
Falkal, P., Bogarts, B., Greve, B., et al(1992) Loss of sylvian fissure asymmetry in schizophrenia. A quantitative post mortem study. Schizophrenia Research, 7, 23–32.CrossRefGoogle Scholar
Falkal, P., Bogarts, B., Greve, B., Schneider, T., et al(1995) Disturbed planum temporale asymmetry in schizophrenia. A quantitative post-mortem study. Schizophrenia Research, 14, 161–176.CrossRefGoogle Scholar
Geschwind, N. & Galaburda, A. M. (1985) Cerebral lateralisation, biological mechanisms, associations, and pathology: I. A hypothesis and a program for research. Archives of Neurology 42, 428–459.CrossRefGoogle Scholar
Gundersen, H. J. & Jensen, E. B. (1987) The efficacy of systematic sampling in stereology and its prediction. Journal of Microscopy 147, 227–263.CrossRefGoogle Scholar
Gundersen, H. J. & Jensen, E. B., Bendtsen, T. F., Korbo, L., et al(1988) Some new, simple and efficient stereological methods and their use in pathological research and diagnosis. APMIS, 96, 379–394.CrossRefGoogle ScholarPubMed
Habib, M., Robichon, F., Levrier, O., et al(1995) Diverging asymmetries of temporo-parietal cortical areas: a reappraisal of Geschwind/Galaburda theory. Brain and Language, 48, 238–258.CrossRefGoogle Scholar
Hoff, A. L., Riordan, H., O'Donnell, D., et al(1992) Anomalous lateral sulcus asymmetry and cognitive function in first-episode schizophrenia. Schizophrenia Bulletin, 18, 257–272.CrossRefGoogle ScholarPubMed
Kleinschmidt, A., Falkal, P., Huang, Y., et al(1994) In vivo morphometry of planum temporale asymmetry in first-episode schizophrenia. Schizophrenia Research, 12, 9–18.CrossRefGoogle ScholarPubMed
Kulynych, J. J., Vladar, K., Fantie, B. D., et al(1995) Normal asymmetry of the planum temporale in patients with schizophrenia. Three-dimensional cortical morphometry with MRI. British Journal of Psychiatry, 166, 742–749.CrossRefGoogle ScholarPubMed
Office of Population Censuses and Surveys (1991) Standard Occupational Classification. London: HMSO Google Scholar
Pacha, J. C., Roberts, N., Vock, P., et al (1993) Vertical LM sectioning and parallel CT scanning designs for stereology: application to the human lung. Journal of Microscopy 170, 9–24.CrossRefGoogle Scholar
Petty, R. G., Barta, P. E., Pearison, G. D., et al (1995) Reversal of asymmetry of the planum temporale in schizophrenia. American Journal of Psychiatry, 152, 715–721.Google ScholarPubMed
Rossi, A., Stratta, P., Mattel, P., et al (1992) Planum temporale in schizophrenia: a magnetic resonance study. Schizophrenia Research, 7, 19–22.CrossRefGoogle ScholarPubMed
Selemon, L. D., Rajkowska, G. & Goldman Rakic, P. S. (1995) Abnormally high neuronal density in the schizophrenic cortex. A morphometric analysis of prefrontal area 9 and occipital area 17. Archives of General Psychiatry, 52, 805–818.CrossRefGoogle ScholarPubMed
Spitzer, R. L., Endicott, J. & Robins, E. (1978) Research Diagnostic Criteria (RDC) for a Selected Group of Functional Disorders. New York: New York State Psychiatric Institution, Biometrics Research Division.Google Scholar
Steinmetz, H., Rademacher, J., Huang, Y. X., et al (1989) Cerebral asymmetry: MR planimetry of the human planum temporale. Journal of Computer Assisted Tomography, 12, 996–1005.CrossRefGoogle Scholar
Steinmetz, H., Rademacher, J., Huang, Y. X., Jancke, L., et al (1990) Total surface of temporoparietal intrasyivian cortex: diverging left-right asymmetries. Brain and Language, 39, 357–372.CrossRefGoogle ScholarPubMed
Steinmetz, H., Rademacher, J., Huang, Y. X., Jancke, L., Volkmann, J., Jancke, L., et al (1991) Anatomical left-right asymmetry of language-related temporal cortex is different in left- and right-handers. Annals of Neurology 29, 315–319.CrossRefGoogle ScholarPubMed
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