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Does Tryptophan Potentiate Clomipramine in the Treatment of Agoraphobic and Social Phobic Patients?

Published online by Cambridge University Press:  29 January 2018

J. C. Pecknold ,
D. J. McClure ,
L. Appeltauer ,
T. Allan  and
L. Wrzesinski
J. C. Pecknold
Affiliation:
Department of Medicine, McGill University; Chief, Psychopharmacology Services, St Mary's Hospital; and Director, Behaviour Therapy Unit, St Mary's Hospital, 3830 Lacombe, Montreal, Quebec, Canada H3T 1M5
D. J. McClure
Affiliation:
Department of Medicine, McGill University, St Mary's Hospital
L. Appeltauer
Affiliation:
St Mary's Hospital
T. Allan
Affiliation:
St Mary's Hospital
L. Wrzesinski
Affiliation:
St Mary's Hospital
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Summary

A 10 week double blind study of 24 agoraphobics and 16 social phobics all on clomipramine compared the effect of adding tryptophan or placebo. Tryptophan did not potentiate the beneficial effect of clomipramine on phobic avoidance, phobic fears or the incidence of panic attacks. Neither was the presence of depression a factor of outcome.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 140 , Issue 5 , May 1982 , pp. 484 - 490
Copyright
Copyright © Royal College of Psychiatrists, 1982 

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