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The Camberwell Collaborative Depression Study II. Investigation of Family Members

Published online by Cambridge University Press:  02 January 2018

P. McGuffin ,
R. Katz ,
J. Aldrich  and
P. Bebbington
P. McGuffin
Affiliation:
University of Wales College of Medicine
R. Katz
Affiliation:
Institute of Psychiatry
J. Aldrich
Affiliation:
MRC Social Psychiatry Unit, Institute of Psychiatry
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Abstract

Out of a consecutive series of 130 potential probands with recent onsets of depression, 124 were deemed ‘in scope’ for a family interview study of social and genetic influences on depression. We were able to interview first-degree relatives of 83 probands (67% of those families ‘in scope’). Unexpectedly, interviewed first-degree relatives had, on average, a significantly lower occupational status than the depressed probands. However, the rates of depression among the first-degree relatives were high. Based on a PSE-Catego classification, 17.2% of 244 relatives were current ‘cases' of depression at the time of interview. This was significantly greater than the estimated population prevalence. Using a Past History Schedule in combination with the PSE, the lifetime prevalence of depressive illness, expressed as the proportion who had ever fulfilled PSE-Catego case criteria, was 38.9%. High rates of psychiatric treatment were also found in family members. The lifetime prevalence of any form of hospital treatment for depression in 315 first-degree relatives was 15.5%. This gives an age-corrected morbidity risk to age 65 years of 24.6%, as compared with a population estimate of 8.9%. In common with previous studies, significantly higher rates of depression were found among female than among male first-degree relatives for broader categories of disorder, but there was a small and non-significant excess of men among those relatives who had received in-patient treatment for depression. This apparent lessening of sex differences with more severe categories was not supported by an examination of ‘lifetime ever’ depressive symptoms, where severity was expressed as highest ever PSE-Catego-ID level. Here the proportion of women who had ever had depressive symptoms remained higher throughout the upper range of the Index of Definition. The findings raise the possibility that male relatives of depressed probands under-report their symptoms, but that their doctors compensate by adopting a lower threshold of psychiatric referral when faced with depressive symptoms in a man.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 152 , Issue 6 , June 1988 , pp. 766 - 774
Copyright
Copyright © Royal College of Psychiatrists, 1988 

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References

Andreason, N. C., Rice, J., Endicott, J., Reich, T. & Coryell, W. (1986) The family history approach to diagnosis. Archives of General Psychiatry, 43, 421–429.Google Scholar
Bebbington, P. (1985) Psychosocial aetiology of schizophrenia and affective disorders In Psychiatry (ed. Michaels, R.). Philadelphia: Lippincott.Google Scholar
Bebbington, P. (1987) The social epidemiology of clinical depression In Handbook of Studies on Social Psychiatry (eds Henderson, A. S. & Burrows, G.). Amsterdam: Elsevier.Google Scholar
——, Hurry, J., Tennant, C., Sturt, E. & Wing, J. K. (1981) Epidemiology of mental disorders in Camberwell. Psychological Medicine, 11, 561–579.Google Scholar
——, Brugha, T., MacCarthy, B., Potter, J., Sturt, E., Wykes, T., Katz, R. & McGuffin, P. (1988) The Camberwell Collaborative Depressive Study – I. Depressed probands: adversity and the form of depression. British Journal of Psychiatry, 152, 754–765.Google Scholar
Bernadt, M. W., Mumford, J., Taylor, C., Smith, B. & Murray, R. M. (1982) Comparison of questionnaire and laboratory tests in the detection of excessive drinking and alcoholism. The Lancet, i, 325–328.Google Scholar
Bertelsen, A., Harvald, B. & Hauge, M. (1977) A Danish twin study of manic-depressive disorders. British Journal of Psychiatry, 130, 330–351.Google Scholar
Brown, G. W. & Harris, T. (1978) The Social Origins of Depression. London: Tavistock.Google Scholar
Brugha, T., Sturt, E., MacCarthy, B., Potter, J., Wykes, T. & Bebbington, P. (1987) The Interview Measure of Social Relationships: the description and evaluation of a survey instrument for assessing personal social relationships. Social Psychiatry, 22, 123–128.CrossRefGoogle ScholarPubMed
Bucher, K. D., Elston, R. C., Green, R., Whybrow, P., Helzer, J., Reich, T., Clayton, P. & Winokur, G. (1981) The transmission of manic depressive illness – II. Segregation analysis of three sets of family data. Journal of Psychiatric Research, 15, 65–78.Google Scholar
Carey, G., Gottesman, I. I. & Robins, E. (1980) Prevalence rates for the neuroses: pitfalls in the evaluation of familiality. Psychological Medicine, 10, 437–443.Google Scholar
Eysenck, H. J. & Eysenck, S. B. G. (1975) Manual of the Eysenck Personality Questionnaire. London: Hodder & Stoughton.Google Scholar
Falconer, D. S. (1965) The inheritance of liability to co-twin diseases, estimated from the incidence among relatives. Annals of Human Genetics, 29, 51–76.CrossRefGoogle Scholar
Falconer, D. S. (1981) Introduction to Quantitative Genetics (2nd edn). London: Longman.Google Scholar
Gershon, E. S., Bunney, W. F., Leckman, J. F., Van Eerdewegh, M. & Debauche, B. A. (1976) The inheritance of affective disorders: a review of data and hypotheses. Behavior Genetics, 6, 227–261.Google Scholar
Goldthorpe, J. & Hope, K. (1974) The Social Grading of Occupations: New Approach and Scale. London: Oxford University Press.Google Scholar
Hurry, J., Sturt, E., Bebbington, P. & Tennant, C. (1983) Socio-demographic association with social disablement in a community sample. Social Psychiatry, 18, 113–121.Google Scholar
Kaplan, E. L. & Meier, P. (1958) Non-parametric estimation from incomplete observations. Journal of the American Statistical Association, 53, 457–481.Google Scholar
McGuffin, P., Katz, J. R. & Aldrich, J. (1986) Past and present state examination: the assessment of ‘lifetime ever’ psychopathology. Psychological Medicine, 16, 461–465.CrossRefGoogle ScholarPubMed
—— & Katz, R. (1986) Nature, nurture and affective disorder In The Biology of Depression (ed. Deakin, J. F. W.). London: Royal College of Psychiatrists/Gaskell Press.Google Scholar
Murray, R. M., Reveley, A. M., Reveley, M. A., Shur, E. & Lewis, S. (1985) Genetic and environmental influences in schizophrenia In Genetic Aspects of Human Behaviour (eds Sakai, T. & Tsuboi, T.). Tokyo: Igaku-Shoin.Google Scholar
O'Rourke, D. H., McGuffin, P. & Reich, T. (1983) Genetic analysis of manic depressive illness. American Journal of Physical Anthropology, 62, 51–59.CrossRefGoogle ScholarPubMed
Paykel, E. S. (1978) Contribution of life events to causation of psychiatric illness. Psychological Medicine, 8, 245–253.Google Scholar
Perris, C., Perris, H., Ericsson, U. & Von Knorring, L. (1982) The genetics of depression: a family study of unipolar and neurotic-reactive depressed patients. Archiv für Psychiatrie und Nervenkrankheit, 232, 137–155.Google Scholar
Pollitt, J. (1972) The relationship between genetic and precipitating factors in depressive illness. British Journal of Psychiatry, 121, 67–70.Google Scholar
Rao, D. C., Morton, N. E. & Cloninger, C. R. (1979) Path analysis under generalised assortative mating – I. Theory. Genetic Research (Cambridge), 33, 175–188.Google Scholar
Reich, T., James, J. W. & Morris, C. A. (1972) The use of multiple thresholds in determining the mode of transmission of semi-continuous traits. Annals of Human Genetics, 36, 163–184.Google Scholar
Reich, T., Robins, L. N., Woodruff, R. A., Taibleson, M., Rich, C. & Cunningham, L. (1975) Computer assisted derivation of a screening interview for alcoholism. Archives of General Psychiatry, 32, 847–852.CrossRefGoogle Scholar
Reich, T., Cloninger, C. R., Wette, R. & James, J. (1979) The use of multiple thresholds and segregation analysis in analysing the phenotypic. Annals of Human Genetics, 42, 371.Google Scholar
Reich, T., Cloninger, C. R., Suarez, B. & Rice, J. (1982) Genetics of the affective disorders In Handbook of Psychiatry, Psychoses of Unknown Aetiology (eds Wing, J. K. & Wing, L.). Cambridge: Cambridge University Press.Google Scholar
Rice, J., Cloninger, C. R. & Reich, T. (1978) Multifactorial inheritance with cultural transmission and assortative mating – I. Description of basic properties of unitary models. American Journal of Human Genetics, 30, 618–643.Google ScholarPubMed
Rice, J., Reich, T., Andreason, N. C., Lavori, J. et al (1984) Sex related differences in depression – familial evidence. Journal of Affective Disorders, 7, 199–210.Google Scholar
Schulz, B. (1932) Irbpathologie der Schizophrenie. Zeitschrift für die gesamte Neurologie und Psychiatrie, 143, 175–293.Google Scholar
Shapiro, R. W. (1970) A twin study of non-endogenous depression. Acta Jutlandica, XLII (publications of the University of Aarhus).Google Scholar
Slater, E. & Shields, J. (1969) Genetic aspects of anxiety In Studies of Anxiety (ed. Lader, M. H.). British Journal of Psychiatry Special Publication No. 3. Oxford: Headley Brothers.Google Scholar
Slater, E. & Cowie, V. (1971) The Genetics of Mental Disorders. Oxford: Oxford University Press.Google Scholar
Stenstedt, A. (1952) A study of manic depressive psychosis: clinical, social and genetic investigations. Acta Psychiatrica Scandinavica, Suppl. 79.Google Scholar
Stenstedt, A. (1966) Genetics of neurotic depression. Acta Psychiatrica Scandinavica, 42, 392–409.Google Scholar
Sturt, E., Kumakara, N. & Der, G. (1984) How depressing life is – lifelong morbidity risk for depressive disorder in the general population. Journal of Affective Disorder, 7, 109–122.Google Scholar
Tennant, C., Smith, A., Bebbington, P. & Hurry, J. (1981) Parental loss in childhood: relationship to adult psychiatric impairment and contact with psychiatric services. Archives of General Psychiatry, 38, 309–314.Google Scholar
Torgersen, S. (1986) Genetic factors in moderately severe and mild affective disorders. Archives of General Psychiatry, 43, 222–226.Google Scholar
Weissman, M. M. & Klermann, G. L. (1977) Sex differences and the epidemiology of depression. Archives of General Psychiatry, 34, 98–111.Google Scholar
Wing, J. K., Cooper, J. E. & Sartorius, N. (1974) The Measurement and Classification of Psychiatric Symptoms. Cambridge: Cambridge University Press.Google Scholar
Wing, J. K. & Sturt, E. (1978) The PSD-ID-CATEGO System Supplementary Manual (mimeo). London: Medical Research Council.Google Scholar
Wing, J. K., Bebbington, P., Hurry, J. & Tennant, C. (1981) The prevalence in the general population of disorders familiar to psychiatrists in hospital practice In What is a Case? The Problem of Definitions in Psychiatric Community Surveys (eds Wing, J., Bebbington, P. & Robins, L.). London: Grant McLntyre.Google Scholar
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