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Bipolar Affective Puerperal Psychosis Associated with Consanguinity

Published online by Cambridge University Press:  02 January 2018

Nick Craddock ,
Ian Brockington ,
Rebecca Mant ,
Elizabeth Parfitt ,
Peter McGuffin  and
Mike Owen
Nick Craddock*
Affiliation:
University of Birmingham, Queen Elizabeth Psychiatric Hospital, Birmingham B15 2QZ
Ian Brockington
Affiliation:
University of Birmingham
Rebecca Mant
Affiliation:
Departments of Psychological Medicine and Medical Genetics, University of Wales College of Medicine, Heath Park, Cardiff CF4 4XN
Elizabeth Parfitt
Affiliation:
Departments of Psychological Medicine and Medical Genetics, University of Wales College of Medicine
Peter McGuffin
Affiliation:
University of Wales College of Medicine
Mike Owen
Affiliation:
Departments of Psychological Medicine and Medical Genetics, University of Wales College of Medicine
*
∗Wellcome Trust Research Fellow, Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff CF4 4XN
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Abstract

Most clinical and genetic evidence suggests that puerperal psychosis is closely related to bipolar affective disorder. During a linkage study of bipolar disorder we ascertained a British family in which puerperal psychosis was associated with consanguinity in three sisters. All three subjects had lifetime RDC diagnoses of bipolar I or manic disorder. An inbred brother also had bipolar I disorder. The only female member of the sibship to escape puerperal psychosis was outbred. These findings are consistent with several genetic models for bipolar disorder in this family. The most interesting possibility is a single major susceptibility locus of recessive effect. Under this assumption, the family could be used for homozygosity mapping to help localise the putative recessive locus. If other inbred families can be found in which the same putative recessive locus is operating, the power to localise the gene by homozygosity mapping would be greatly increased.

Type
Peer Review
Information
The British Journal of Psychiatry , Volume 164 , Issue 3 , March 1994 , pp. 359 - 364
Copyright
Copyright © 1994 The Royal College of Psychiatrists 

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References

Adams, M. S. & Neel, J. V. (1967) Children of incest. Pediatrics, 40, 55–62.CrossRefGoogle ScholarPubMed
American Psychiatric Association (1987) Diagnostic and Statistical Manual of Mental Disorders (3rd edn, revised) (DSM–III–R). Washington, DC: APA.Google Scholar
Baird, P. A. & McGillivray, B. (1982) Children of incest. Journal of Pediatrics, 101, 854–857.Google Scholar
Bratfos, O. & Haug, J. O. (1966) Puerperal mental disorders in manic-depressive females. Acta Psychiatrica Scandinavica, 42, 285–294.CrossRefGoogle ScholarPubMed
Brockington, I. F., Cernik, K. F., Schofield, E. M., et al (1981) Puerperal psychosis. Phenomena and diagnosis. Archives of General Psychiatry, 38, 829–833.CrossRefGoogle ScholarPubMed
Carter, C. O. (1967) Risk to offspring of incest. Lancet i, 436.Google Scholar
Davidson, J. & Robertson, E. (1985) A follow-up study of postpartum illness, 1946–1978. Acta Psychiatrica Scandinavica, 71, 451–457.CrossRefGoogle Scholar
Dean, C. & Kendell, R. E. (1981) The symptomatology of puerperal illnesses. British Journal of Psychiatry, 139, 128–133.Google Scholar
Dean, C., Williams, R. J. & Brockington, I. F. (1989) Is puerperal psychosis the same as bipolar manic-depressive disorder? A family study. Psychological Medicine, 19, 637–647.CrossRefGoogle ScholarPubMed
Edwards, A. W. F. (1972) Likelihood. An Account of the Statistical Concept of Likelihood and its Application to Scientific Inference. Cambridge: Cambridge University Press.Google Scholar
Endicott, J. & Spitzer, R. L. (1978) A diagnostic interview. The Schedule for Affective Disorders and Schizophrenia. Archives of General Psychiatry, 35, 837–844.Google Scholar
Herlofsen, H. B. & Odegard, O. (1955) A study of psychotic patients of consanguineous parentage. Acta Genetica, 5, 391–402.Google Scholar
Kadramas, A., Winokur, G. & Crowe, R. (1979) Postpartum mania. British Journal of Psychiatry, 135, 551–554.CrossRefGoogle Scholar
Kendell, R. E., Chalmers, J. C. & Platz, C. (1987) Epidemiology of puerperal psychoses. British Journal of Psychiatry, 150, 662–673.CrossRefGoogle ScholarPubMed
Lander, E. S. & Boistein, D. (1987) Homozygosity mapping: a way to map human recessive traits with the DNA of inbred children. Science 236, 1567–1570.Google Scholar
McGuffin, P. & Katz, R. (1989) The genetics of depression and manic-depressive disorder. British Journal of Psychiatry, 155, 294–304.Google Scholar
McGuffin, P. & Sargeant, M. P. (1991) Genetic markers and affective disorder. In The New Genetics of Mental Illness (eds P. McGuffin & R. Murray). Oxford: Butterworth-Heinemann.Google Scholar
McNeil, T. (1986) A prospective study of postpartum psychoses in a high-risk group. I. Clinical characteristics of the current postpartum episodes. Acta Psychiatrica Scandinavica, 74, 205–216.Google Scholar
Manuzza, S., Fyer, A., Klein, D., et al (1986) Schedule for Affective Disorders and Schizophrenia - Lifetime Version modified for the study of anxiety disorders. Journal of Psychiatric Research, 20, 317–325.Google Scholar
Meltzer, E. S. & Kumar, R. (1985) Puerperal mental illness. Clinical features and classification: a study of 142 mother-and-baby admissions. British Journal of Psychiatry, 147, 647–654.Google Scholar
Miller, C. A. & Krachmer, J. H. (1986) Corneal diseases. In Goldberg's Genetic and Metabolic Eye Disease (ed. Renie, W. A.), pp. 297–367. Boston: Little, Brown & Co.Google Scholar
Owen, M. (1992) Will schizophrenia become a graveyard for molecular geneticists? Psychological Medicine, 22, 289–292.Google Scholar
Platz, C. & Kendeli, R. E. (1988) A matched-control follow-up and family study of ‘puerperal psychoses’. British Journal of Psychiatry, 153, 90–94.Google Scholar
Protheroe, C. (1969) Puerperal psychoses: a long term study 1927–1961. British Journal of Psychiatry, 115, 9–30.Google Scholar
Reich, T. & Winokur, G. (1970) Postpartum psychoses in patients with manic depressive disease. Journal of Nervous and Mental Disease, 151, 60–68.Google Scholar
Schellenberg, G. D., Martin, G. M., Wijsman, E. M., et al (1992) Homozygosity mapping and Werner's syndrome. Lancet 339, 1002.Google Scholar
Schopf, J., Bryois, C., Jonquiere, M., et al (1985) A family hereditary study of post-partum ‘psychoses’. European Archives of Psychiatry and Neurological Sciences, 235, 164–170.CrossRefGoogle ScholarPubMed
Seemanova, E. (1971) A study of children of incestuous matings. Human Heredity, 21, 108–128.Google Scholar
Spitzer, R. L., Endicott, J. & Robins, E. (1978) Research Diagnostic Criteria. Rationale and reliability. Archives of General Psychiatry, 35, 773–782.CrossRefGoogle ScholarPubMed
Thuwe, I. (1974) Genetic factors in puerperal psychosis. British Journal of Psychiatry, 125, 378–385.Google Scholar
Tsuang, M. T. & Faraone, S. V. (1990) The Genetics of Mood Disorders. Baltimore: Johns Hopkins University Press.Google Scholar
Vogel, F. & Motulsky, A. G. (1986) Human Genetics. Problems and Approaches. Berlin: Springer-Verlag.CrossRefGoogle Scholar
Wald, A. (1947) Sequential Analysis. New York: Wiley.Google Scholar
Whalley, L. J., Roberts, D. F., Wentzel, J., et al (1982) Genetic factors in puerperal affective psychoses. Acta Psychiatrica Scandinavica, 65, 180–193.Google Scholar
Wieck, A., Kumar, R., Hirst, A. D., et al (1991) Increased sensitivity of dopamine receptors and recurrence of affective psychosis after childbirth. British Medical Journal, 303, 613–616.CrossRefGoogle ScholarPubMed
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