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Single Photon Emission Computerised Tomography in Elderly Patients with Alzheimer's Disease and Multi-infarct Dementia

Regional Uptake of Technetium-Labelled HMPAO Related to Clinical Measurements

Published online by Cambridge University Press:  02 January 2018

Ian G. Mckeith ,
Julia Cook ,
Ruth Adams ,
E. Marjorie Irvine ,
Alan E. S. Simpson  and
Peter H. Bartholomew
Julia Cook
Affiliation:
University Department of Psychiatry of Old Age, Brighton Clinic, Newcastle General Hospital, Newcastle upon Tyne NE4 6BE
Ruth Adams
Affiliation:
University Department of Psychiatry of Old Age, Brighton Clinic, Newcastle General Hospital, Newcastle upon Tyne NE4 6BE
E. Marjorie Irvine
Affiliation:
Regional Department of Medical Physics, Newcastle General Hospital
Alan E. S. Simpson
Affiliation:
Regional Department of Medical Physics, Newcastle General Hospital
Peter H. Bartholomew
Affiliation:
Regional Department of Medical Physics, Queen Elizabeth Hospital, Gateshead NE9 6SX
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Abstract

Single photon emission computerised tomography (SPECT) was used to measure regional brain uptake of technetium-99m hexamethyl-propyleneamine oxine (Tc99m-HMPAO) in elderly patients with Alzheimer's disease (AD), multi-infarct dementia (MID) and normals (n = 20 in each group). Different patterns of uptake were found between groups when cortical uptake was normalised to cerebellar uptake. Reductions occurred in all regions in AD, being most marked in temporal and posterior parietal areas. Significant correlations were found in AD between memory impairment and decreased temporal uptake bilaterally, and between duration of illness and reduced uptake in most brain regions. MID patients showed higher uptake in the anterior parietal region than did the other groups. A variable comparing anterior to posterior uptake significantly discriminated the two patient groups.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 163 , Issue 5 , November 1993 , pp. 597 - 603
Copyright
Copyright © Royal College of Psychiatrists, 1993 

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