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Schizophrenia and XO/XX/XXX Mosaicism

Published online by Cambridge University Press:  29 January 2018

P. J. V. Beumont  and
Richard Mayou
P. J. V. Beumont
Affiliation:
Department of Psychiatry, University of Oxford. Bethlem Royal and Maudsley Hospitals
Richard Mayou
Affiliation:
Bethlem Royal and Maudsley Hospitals
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Extract

Abnormalities of sex chromosomes are associated with various forms of neuropsychiatric disorder, and Polani (1969) has reviewed the literature. While there were numerous reports associating the XXY and XXX constitutions with psychiatric disorder, the position was somewhat different with regard to Turner's syndrome. The purpose of this paper is to describe a patient who was shown to have the clinical pattern of Turner's Syndrome and an XO/XX/XXX mosaic chromosome pattern, and who presented with a schizophrenic illness.

Type
Abstract
Information
The British Journal of Psychiatry , Volume 118 , Issue 544 , March 1971 , pp. 349 - 350
Copyright
Copyright © Royal College of Psychiatrists, 1971 

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References

Kaplan, A. R., and Cotton, J. E. (1968). ‘Chromosomal abnormalities in female schizophrenics.’ Journal of Nervous and Mental Diseases, 147, 402.CrossRefGoogle ScholarPubMed
Maclean, N., Harnden, D. G., Court Brown, W. M., Bond, J., and Mantle, D. J. (1964). ‘Sex chromosome abnormalities in new-born babies.’ Lancet, 286–90.CrossRefGoogle Scholar
Polani, P. E. (1969). ‘Abnormal sex chromosomes and mental disorder.’ Nature, 223, 680.Google Scholar
Slater, E., and Zilkha, K. (1961). Case report. Proceedings of the Royal Society of Medicine, 54, 674.Google Scholar
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