Hostname: page-component-586b7cd67f-rdxmf Total loading time: 0 Render date: 2024-11-26T05:21:29.342Z Has data issue: false hasContentIssue false
  • English
  • Français

Effect of substance misuse in early psychosis

Published online by Cambridge University Press:  06 August 2018

Jean Addington  and
Donald Addington
Jean Addington
Affiliation:
Department of Psychiatry, University of Calgary, Alberta, Canada
Donald Addington
Affiliation:
Department of Psychiatry, University of Calgary, Alberta, Canada
Get access Rights & Permissions [Opens in a new window]

Abstract

Background Studies examining the temporal relationship between substance use and the onset of psychotic symptoms in schizophrenia are inconclusive.

Method Three groups of out-patients with schizophrenia were compared on onset of illness, symptoms and quality of life. Fifty-one subjects had no past or present history of substance misuse, 29 subjects had a history of past substance misuse occurring around the onset of their illness, and 33 subjects were currently misusing substances.

Results Current substance misusers had poorer quality of life scores and less negative symptoms than the non-users. Those who had a past history of substance misuse had a significantly earlier age of onset than those with no substance use.

Conclusions Attention should be paid to substance misuse present at the first episode. Treatment for schizophrenia should begin even though a diagnosis of drug-induced psychosis cannot be ruled out.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 172 , Issue S33: Verging on reality , June 1998 , pp. 134 - 136
Copyright
Copyright © 1998 The Royal College of Psychiatrists 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Addington, J. & Addington, D. (1997) Cognitive and social functioning in schizophrenia out-patients who abuse substances. Journal of Psychiatry and Neuroscience, 22, 99–104.Google Scholar
Addington, J. & Addington, D. (1998) Neurocognitive and social functioning in schizophrenia. Schizophrenia bulletin, in press.Google Scholar
American Psychiatric Association (1987) Diagnostic and Statistical Manual for Mental Disorders (3rd edn, revised) (DSM–III–R). Washington, DC: APA.Google Scholar
Breakey, W. R., Goodell, H., Lorenz, P. C., et al (1974) Hallucinogenic drugs as precipitants of schizophrenia. Psychological Medicine, 4, 255–261.Google Scholar
Dixon, L., Haas, G., Weiden, P., et al (1991) Drug abuse in schizophrenic patients: clinical correlates and reasons for use. American Journal of Psychiatry 148, 224–230.Google ScholarPubMed
Hambrecht, M. & Hafner, H. (1996) Substance abuse and the onset of schizophrenia. Biological Psychiatry 39, 1–9.Google Scholar
Heinrichs, D. W., Hanlon, T. E. & Carpenter, W.T. (1984) The Quality of Life Scale: an instrument for rating the schizophrenic deficit syndrome. Schizophrenia bulletin, 10, 388–398.Google Scholar
Kay, S. R., Fiszbein, A. & Opler, L. A. (1987) The positive and negative syndrome Scale PANSS for Schizophrenia. Schizophrenia bulletin, 13, 261–276.Google Scholar
Loebel, A. D., Lieberman, J. A., Alvir, J. M. J., et al (1992) Duration of psychosis and outcome in first-episode schizophrenia. American Journal of Psychiatry 149, 1183–1188.Google ScholarPubMed
Mueser, K.T., Bellack, A. S. & Blanchard, J. J. (1992) Comorbidity of schizophrenia and substance abuse: implications for treatment. Journal of Clinical and Consulting Psychology, 60, 845–856.Google Scholar
Richard, M. L., Liskow, B. I. & Perry, P. J. (1985) Recent psychostimulant use in hospitalized schizophrenics. Journal of Clinical Psychiatry, 46, 79–83.Google Scholar
Schneier, F. R. & Siris, S. G. (1987) A review of psychoactive substance use and abuse in schizophrenia. Journal of Nervous and Mental Disease, 175, 641–652.CrossRefGoogle ScholarPubMed
Spitzer, R. L., Williams, J. B., Gibbon, M., et al (1990) User's Guide for the Structured Clinical Interview for DSM–lll–R SCID. Washington, DC: American Psychiatric Press.Google Scholar
Szymanski, S. R., Cannon, T. D., Gallacher, F., et al (1996) Course of treatment response in first-episode and chronic schizophrenia. American Journal of Psychiatry, 153, 519–525.Google ScholarPubMed
Tsuang, M.T., Simpson, J. C. & Kronfol, Z. (1982) Subtypes of drug abuse with psychosis: demographic characteristics clinical features and family history. Archives of General Psychiatry 39, 141–147.Google Scholar
Turner, W. M. & Tsuang, M. T. (1990) Impact of substance abuse on the course and outcome of schizophrenia, Schizophrenia bulletin, 16, 87–95.Google Scholar
Wyatt, R. J. (1991) Neuroleptics and the natural course of schizophrenia. Schizophrenia bulletin, 17, 325–351.CrossRefGoogle ScholarPubMed
Submit a response

eLetters

No eLetters have been published for this article.