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The Effect of an Altered Time Regime on Biological Rhythms in a 48-hour Periodic Psychosis

Published online by Cambridge University Press:  29 January 2018

F. A. Jenner ,
J. C. Goodwin ,
M. Sheridan ,
Ilse J. Tauber  and
Mary C. Lobban
F. A. Jenner
Affiliation:
Medical Research Council Unit for Research on the Chemical Pathology of Mental Disorders, Hollymoor Clinic, Hollymoor Hospital, Northfield, Birmingham, 31
J. C. Goodwin
Affiliation:
Medical Research Council Unit for Research on the Chemical Pathology of Mental Disorders, Hollymoor Clinic, Hollymoor Hospital, Northfield, Birmingham, 31
M. Sheridan
Affiliation:
Medical Research Council Unit for Research on the Chemical Pathology of Mental Disorders, Hollymoor Clinic, Hollymoor Hospital, Northfield, Birmingham, 31
Ilse J. Tauber
Affiliation:
Medical Research Council Unit for Research on the Chemical Pathology of Mental Disorders, Hollymoor Clinic, Hollymoor Hospital, Northfield, Birmingham, 31
Mary C. Lobban
Affiliation:
Division of Human Physiology, National Institute for Medical Research, Hampstead, London, N.W.3
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Extract

Jenner, Gjessing, Cox, Davies-Jones, Hullin, and Hanna (1967) have presented some biochemical and clinical studies of a patient who showed a remarkably precisely timed manic-depressive psychosis. For the last eleven years the patient has been alternately depressed and lethargic for 24 hours, then elated for 24 hours, and so on almost without fail. Harding, Jeavons, Jenner, Drummond, Sheridan and Howells (1966) published electroencephalographic studies showing the 48-hour rhythm in the patient's electroencephalogram. The harmonic mean, the mean abundance and variability of the alpha rhythm all showed a striking 48-hour cycle. A number of similar patients have been described and are conveniently listed by Menninger-Lerchenthal (1960), Richter (1960), and Bunney and Hartmann (1965). Jenner (1965) made some suggestions about possibly heuristically helpful electronic analogues which might appropriately represent some of the underlying mechanisms of the 48-hour syndromes.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 114 , Issue 507 , February 1968 , pp. 215 - 224
Copyright
Copyright © Royal College of Psychiatrists, 1968 

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