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Catechol-O-Methyl Transferase Activity in Patients with Depressive Illness and Anxiety States

Published online by Cambridge University Press:  29 January 2018

Ralph Shulman ,
John Griffiths  and
Patricia Diewold
Ralph Shulman
Affiliation:
Vancouver General Hospital; and Department of Psychiatry, Faculty of Medicine, University of British Columbia, Vancouver, BC
John Griffiths
Affiliation:
Veterans' Hospital, La Jolla, California
Patricia Diewold
Affiliation:
Vancouver General Hospital, Vancouver, BC
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Summary

Erythrocyte catechol-O-methyl transferase (COMT) activity was studied in 65 patients with depressive illness and anxiety states. A hypothesis that measurement of this enzyme might have some value as an aid to diagnosis and as an index of clinical recovery has not been confirmed. In patients with endogenous depression, agitated subjects had COMT levels significantly higher than normal (P < ·01) and retarded subjects had levels significantly lower than normal (P < ·02). These observations are congruent with some reports of high and low urinary MHPG excretion in patients with depression. Further data correlating COMT assays with catecholamine metabolites in depressed patients may reveal homogeneous biochemical subgroups which could serve as a guide to rational therapy.

Type
Papers
Information
The British Journal of Psychiatry , Volume 132 , Issue 2 , February 1978 , pp. 133 - 138
Copyright
Copyright © Royal College of Psychiatrists, 1978 

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References

Beckmann, H. & Goodwin, F. K. (1975) Antidepressant response to tricyclics and urinary MHPG in unipolar patients: clinical response to imipramine or amitriptyline. Archives of General Psychiatry, 32, 17–21.CrossRefGoogle ScholarPubMed
Cochran, W. G. & Cox, G. M. (1957) Experimental Designs (Second edition). New York: Wiley.Google Scholar
Cohn, C. K., Dunner, D. L. & Axelrod, J. (1970) Reduced catechol-O-methyl-transferase activity in red blood cells of women with primary affective disorder. Science, 170, 1323–4.CrossRefGoogle Scholar
Deleon-Jones, F., Maas, J. W., Dekirmenjian, H. et al (1975) Diagnostic subgroups of affective disorders and their urinary excretion of catecholamine metabolites. American Journal of Psychiatry, 132, 1141–8.Google Scholar
Dunner, D. L., Cohn, C. K., Gershon, E. S. et al (1971) Differential catechol-O-methyltransferase activity in unipolar and bipolar affective illness. Archives of General Psychiatry, 25, 348–53.CrossRefGoogle ScholarPubMed
Feighner, J. P., Robins, E., Guze, S. B. et al (1972) Diagnostic criteria for use in psychiatric research. Archives of General Psychiatry, 26, 57–63.CrossRefGoogle ScholarPubMed
Gershon, E. S. & Jonas, W. Z. (1975) Erythrocyte soluble catechol-O-methyltransferase activity in primary affective disorders. A clinical and genetic study. Archives of General Psychiatry, 32, 1351–6.CrossRefGoogle ScholarPubMed
Griffiths, J. & Linklater, H. (1972) A radioisotope method for catechol-O-methyl transferase in blood. Clinical Chimica Acta, 39, 383–9.CrossRefGoogle ScholarPubMed
Rosenblatt, S. & Chanley, J. D. (1965) Differences in the metabolism of norepinephrine in depression. Archives of General Psychiatry, 13, 495.CrossRefGoogle Scholar
Schildkraut, J. J. (1974) Current status of biological and psychopathological criteria for classifying the depressive disorders and predicting responses to treatment. Psychopharmacological Bulletin, 10, 5–25.Google Scholar
White, H. L., McLeod, M. N. & Davidson, J. R. T. (1976) Catechol-O-methyltransferase in red blood cells of schizophrenic, depressed, and normal human subjects. British Journal of Psychiatry, 128, 184–7.CrossRefGoogle ScholarPubMed
Wing, J. K., Cooper, J. E. & Sartorius, N. (1974) The Measurement and Classification of Psychiatric Symptoms. Cambridge University Press.Google Scholar
Winokur, G. & Clayton, P. (1966) Family history studies: two types of affective disorders separated according to genetic and clinical factors. Recent Advances in Biological Psychiatry, 9, 35–50.Google ScholarPubMed
Wyatt, R. J., Portnoy, B., Kupfer, D. J. et al (1971) Resting plasma catecholamine concentrations in patients with depression and anxiety. Archives of General Psychiatry, 24, 65–70.CrossRefGoogle ScholarPubMed
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