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Biperiden and Piroheptine Do Not Affect the Serum Level of Zotepine, a New Antipsychotic Drug

Published online by Cambridge University Press:  02 January 2018

K. Otani ,
T. Hirano ,
T. Kondo ,
S. Kaneko ,
Y. Fukushima ,
K. Noda  and
Y. Tashiro
K. Otani*
Affiliation:
Department of Neuropsychiatry, Hirosaki University Hospital, Japan
T. Hirano
Affiliation:
Department of Neuropsychiatry, Hirosaki University Hospital, Japan
T. Kondo
Affiliation:
Department of Neuropsychiatry, Hirosaki University Hospital, Japan
S. Kaneko
Affiliation:
Department of Neuropsychiatry, Hirosaki University Hospital, Japan
Y. Fukushima
Affiliation:
Department of Neuropsychiatry, Hirosaki University Hospital, Japan
K. Noda
Affiliation:
Department of Neuropsychiatry, Hirosaki University Hospital, Japan
Y. Tashiro
Affiliation:
The Research Laboratories, Fujisawa Pharmaceutical Co, Ltd, Osaka, Japan
*
∗Department of Neuropsychiatry, Hirosaki University Hospital, Hirosaki, Japan
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Abstract

The effects of biperiden and piroheptine on the serum level of zotepine were studied in 15 schizophrenic and 6 mentally retarded in-patients. Neither of these anticholinergic drugs affected the serum level of zotepine nor caused significant side-effects. In the schizophrenics the total scores on the BPRS did not change significantly with either combination of drugs.

Type
Brief Reports
Information
The British Journal of Psychiatry , Volume 157 , Issue 1 , July 1990 , pp. 128 - 130
Copyright
Copyright © The Royal College of Psychiatrists 

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