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Cerebrovascular disease and oxidative stress

Part of: Bespoke shallow archive Weizmann

Published online by Cambridge University Press:  01 August 1999

SE Gariballa  and
AJ Sinclair
SE Gariballa
Affiliation:
Sheffield Institute of Studies on Aging, University of Sheffield, Barnsley General Hospital, Barnsley UK
AJ Sinclair
Affiliation:
Academic Department of Geriatric Medicine, University of Birmingham, Birmingham UK
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Abstract

There is strong indirect evidence that free radical production appears to be an important mechanism of brain injury after exposure to ischaemia and reperfusion. Although significant brain damage occurs during an ischaemic episode, new cerebral damage can occur after reperfusion. One proposed mechanism for the brain damage that occurs during reperfusion involves generation of free radicals. Body defences against free radicals depends on the balance between free radical generation and the antioxidant protective defence system. Many of these protective antioxidants are essential nutrients or have essential nutrients as part of their molecule that has to be obtained from diet.

Type
Review Article
Information
Reviews in Clinical Gerontology , Volume 9 , Issue 3 , August 1999 , pp. 197 - 206
Copyright
© Cambridge University Press 1999

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