Hostname: page-component-cd9895bd7-gbm5v Total loading time: 0 Render date: 2024-12-24T13:25:01.008Z Has data issue: false hasContentIssue false
  • English
  • Français

Response to drugs in schizophrenia: the influence of family history, obstetric complications and ventricular enlargement

Published online by Cambridge University Press:  09 July 2009

V. L. Nimgaonkar ,
S. Wessely ,
L. E. Tune  and
R. M. Murray
V. L. Nimgaonkar*
Affiliation:
Institute of Psychiatry, LondonPhipps Clinic, Johns Hopkins Medical School, Baltimore, USA
S. Wessely
Affiliation:
Institute of Psychiatry, LondonPhipps Clinic, Johns Hopkins Medical School, Baltimore, USA
L. E. Tune
Affiliation:
Institute of Psychiatry, LondonPhipps Clinic, Johns Hopkins Medical School, Baltimore, USA
R. M. Murray
Affiliation:
Institute of Psychiatry, LondonPhipps Clinic, Johns Hopkins Medical School, Baltimore, USA
*
1Address for correspondence: Dr V. L. Nimgaonkar, Western Psychiatric Institute and Clinic, 3811 O'Hara Street, Pittsburgh, USA 15217.
Get access Rights & Permissions [Opens in a new window]

Synopsis

A prospective study of antipsychotic drug treatment showed no difference in response between schizophrenic in-patients with or without a familial predisposition to the illness (N = 53). All patients received at least 600 mg chlorpromazine equivalents antipsychotic medication for 6 weeks. Ventricle brain ratios, ratings of cortical sulcal widening and a history of obstetric complications also failed to account for the variability, but early age of onset was associated with unsatisfactory response.

Type
Research Article
Information
Psychological Medicine , Volume 18 , Issue 3 , August 1988 , pp. 583 - 592
Copyright
Copyright © Cambridge University Press 1988

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Baron, M., Gruen, R. & Asnis, L. (1982). Schizophrenia: a comparative study of patients with and without family history. British Journal of Psychiatry 140, 516–517.CrossRefGoogle ScholarPubMed
Bartko, J. J. & Carpenter, W. T. (1976). On the methods and theory of reliability. Journal of Nervous and Mental Diseases. 163, 307–317.CrossRefGoogle ScholarPubMed
Brockington, I. F., Kendell, R. E. & Wainwright, S. (1980 a). Depressed patients with schizophrenic or paranoid symptoms. Psychological Medicine 10, 665–675.CrossRefGoogle ScholarPubMed
Brockington, I. F., Wainwright, S. & Kendell, R. E. (1980 b). Manic patients with schizophrenic or paranoid symptoms. Psychological Medicine 10, 73–83.CrossRefGoogle ScholarPubMed
Cole, J. O., Goldberg, S. C. & David, J. M. (1966). Drugs in the treatment of psychosis: controlled studies. In Psychiatric Drugs (ed. Solomon, P.), pp. 153–180. Grune and Stratton: NewYork.Google Scholar
Crow, T. J., MacMillan, J. F., Johnson, A. L. & Johnstone, E. C. (1986). The Northwick Park study of first episodes of schizophrenics. II. A randomised controlled trial of prophylactic neuroleptic treatment. British Journal of Psychiatry 148, 120–127.CrossRefGoogle Scholar
Csernansky, J. G., Kaplan, J. & Hollister, L. E. (1985). Problems in classification of schizophrenics as neuroleptic responders and nonresponders. Journal of Nervous and Mental Diseases 173, 325–331.CrossRefGoogle ScholarPubMed
Curry, S. H. (1986). Applied clinical pharmacology of schizophrenia. In The Psychopharmacology and Treatment of Schizophrenia (ed. Bradley, P. B. and Hirsch, S. R.), pp. 103–131. Oxford Medical Publications: Oxford.Google Scholar
Davis, J. M. (1976). Comparative doses and costs of antipsychotic medication. Archives of General Psychiatry 33, 858–861.CrossRefGoogle ScholarPubMed
Davison, K. & Bagley, C. R. (1969). Schizophrenia-like psychoses associated with organic disorders of the central nervous system: A review of the literature. In Current Problems in Neuropsychiatry. British Journal of Psychiatry Special Publication 4 (ed. Herrington, R. N.). Headley Brothers: Ashford, Kent.Google Scholar
Eaves, L. J., Kendler, K. S. & Schulz, S. C. (1986). The familial sporadic classification: its power for the resolution of genetic and environmental aetiological factors. Journal of Psychiatric Research 20, 115–130.CrossRefGoogle Scholar
Endicott, J., Andreasen, N. & Spitzer, R. L. (1975). Family History - Research Diagnostic Criteria. New York State Psychiatric Institute: New York.Google Scholar
Endicott, J., Spitzer, R., Fleiss, J. & Cohen, J. (1976). The Global Assessment Scale: A procedure for measuring overall severity of psychiatric disturbance. Archives of General Psychiatry 33, 767–771.CrossRefGoogle Scholar
Galdi, J., Rider, R. O., Silber, D. & Bonato, R. R. (1981). Genetic factors in the response to neuroleptics in schizophrenia: A psychopharmacogenetic study. Psychological Medicine 11, 713–728.CrossRefGoogle ScholarPubMed
Geigy, . Scientific Tables (Documenta Geigy) (1970). (ed. Diem, K. and Lentuer, C.). J. R. Geigy, S. A: Basle.Google Scholar
Gelder, M. G. & Kolakowska, T. (1979). Variability of response to neuroleptics in schizophrenia: clinical, pharmacological and neuroendocrine correlates. Comprehensive Psychiatry 20, 397–408.CrossRefGoogle ScholarPubMed
Gelder, M. G., Gath, D. & Mayou, R. (1983). Oxford Textbook of Psychiatry, pp. 268–270. Oxford University Press: Oxford.Google Scholar
Goldberg, S. C., Klerman, G. L. & Cole, J. O. (1965). Changes in schizophrenic psychopathology and ward behaviour as a function of phenothiazine treatment. British Journal of Psychiatry 111, 120–133.CrossRefGoogle ScholarPubMed
Goldstein, M. J. (1970). Premorbid adjustment, paranoid status and patterns of response of phenothiazines in acute schizophrenics. Schizophrenia Bulletin 3, 24–27.CrossRefGoogle Scholar
Gottesman, I. I. & Shields, J. (1982). Schizophrenia, the Epigenetic Puzzle. Cambridge University Press: Cambridge.Google Scholar
Hirsch, S. R. (1986). Clinical treatment of schizophrenia. In The Psychopharmacology and Treatment of Schizophrenia (ed. Bradley, P. B. and Hirsch, S. R.), pp. 286–339. Oxford Medical Publications: Oxford.Google Scholar
Hollister, L. E. (1974). Clinical differences among phenothiazines in schizophrenics. In. Advances in Biomedical Psychopharmacology, Vol. 9, pp. 667–673. WHO: Geneva.Google Scholar
Hollister, L. E., Overall, J. E., Kimbell, I. & Pokormy, A. (1974). Specific indications for different classes of phenothiazines. Archives of General Psychiatry 30, 94–99.CrossRefGoogle ScholarPubMed
Johnstone, E. C., Crow, T. J., Frith, C. D., Carney, M. W. P. & Price, J. S. (1978). Mechanisms of the antipsychotic effect in the treatment of acute schizophrenia. Lancet i, 848–851.CrossRefGoogle Scholar
Kendler, K. S. & Hays, P. (1982). Familial and sporadic schizophrenia: a symptomatic, prognostic and EEG comparison. American Journal of Psychiatry 139, 1557–1562.Google ScholarPubMed
Klein, D. F. & Rosen, B. (1973). Premorbid asocial adjustment and response to phenothiazine treatment among schizophrenic inpatients. Archives of General Psychiatry 29, 480–485.CrossRefGoogle ScholarPubMed
Kleinman, J. E., Karson, C. N., Weinberger, C. R., Rogol, A. D., Bigelow, L. B., Klein, S. T. & Wyatt, R. J. (1982). Relationship between plasma prolactin concentrations and psychopathology in chronic schizophrenia. Archives of General Psychiatry 39, 655–657.CrossRefGoogle ScholarPubMed
Kleinman, J. E., Karson, C. N., Weinberger, D. R., Freed, W. J., Berman, K. F. & Wyatt, R. J. (1984). Eye-blinking and cerebral ventricular size in chronic schizophrenic patients. American Journal of Psychiatry 141, 1430–1432.Google ScholarPubMed
Kolakowska, T., Gelder, M. G. & Orr, M. W. (1980). Drug-related and illness-related factors in the outcome of chlorpromazine treatment: testing a model. Psychological Medicine 10, 335–343.CrossRefGoogle ScholarPubMed
Kolakowska, T., Williams, A. O., Ardern, M., Reveley, M. A., Madelbrote, B. M., Jambor, K. & Gelder, M. G. (1985). Schizophrenia with good and poor outcome. I. Early clinical features, response to neuroleptics and signs of organic dysfunction. British Journal of Psychiatry 146, 229–239.CrossRefGoogle ScholarPubMed
Krska, J., Sampath, G., Shah, A. & Soni, S. D. C. (1986). Radioreceptor assay of serum neuroleptic levels in psychiatric patients. British Journal of Psychiatry 148, 187–193.CrossRefGoogle ScholarPubMed
Lader, M., (1979). Monitoring plasma concentrations of neuroleptics. Pharmacopsychology 9, 170–177.CrossRefGoogle Scholar
Lancet Editorial (1985). Post-hemorrhagic ventricular dilatation in infants. Lancet ii, 1280–1282.Google Scholar
Lewis, S. W. & Murray, R. M. (1987). Obstetric complications, neurodevelopmental deviance and risk of schizophrenia. Journal of Psychiatric Research 21, 413–422.CrossRefGoogle ScholarPubMed
Lewis, S. W., Reveley, A. M., Reveley, M. A., Chitkara, B. & Murray, R. M. (1987). The familial-sporadic distinction as a strategy in schizophrenia research. British Journal of Psychiatry 15, 306–313.CrossRefGoogle Scholar
Losonczy, M. F., Song, I., Mohs, R. C., Small, N. A., Davidson, M., Johns, C. A. & Davis, K. L. (1986). Correlates of lateral ventricular size in chronic schizophrenia. I. Behavioural and treatment response measures. American Journal of Psychiatry 143, 976–981.Google ScholarPubMed
Luchins, D. J., Lewine, R. R. J. & Meltzer, H. Y. (1984). Lateral ventricular size, psychopathology and medication response in psychoses. Journal of Psychiatric Research 19, 29–44.Google ScholarPubMed
McNeil, T. F. & Kaij, L. (1978). Obstetric factors in the development of schizophrenia: Complications in the births of preschizophrenics and in reproduction by schizophrenic parents. In High Risk and Premorbid Development (ed. Wynne, C., Cromwell, R. L. and Mathysse, S.), pp. 407–429. Wiley: New York.Google Scholar
May, P. R. A., Tuma, A. H., Dixon, W. J., Yale, C., Thiele, D. A. & Kraude, W. H. (1981). Schizophrenia: A follow up study of the results of five forms of treatment. Archives of General Psychiatry 38, 776–784.CrossRefGoogle ScholarPubMed
Montgomery, S. A., Taylor, P. & Montgomery, D. (1983). Development of a schizophrenia scale sensitive to change. Neuropharmacology 17, 1061–1063.CrossRefGoogle Scholar
Murray, R. M. & Murphy, D. L. (1978). Drug response and psychiatric nosology. Psychological Medicine 8, 667–681.CrossRefGoogle ScholarPubMed
Murray, R. M., Lewis, S. W. & Reveley, A. M. (1985). Towards an aetiological classification of schizophrenia. Lancet i, 1023–1026.CrossRefGoogle Scholar
Nasrallah, H. Y., Kuperman, S., Hamra, B. J. & McCalley-Whitters, M. (1983). Clinical differences between schizophrenic patients with and without large cerebral ventricles. Journal of Clinical Psychiatry 44, 407–409.Google ScholarPubMed
Nimgaonkar, V. L., Wessely, S. & Murray, R. M. (1988). Prevalence of perinatal trauma, familiality and structural brain damage in schizophrenic patients. British Journal of Psychiatry (in the press).CrossRefGoogle Scholar
Owen, M. J., Lewis, S. W. & Murray, R. M. (1988). Obstetric complications and cerebral abnormalities in schizophrenia. Psychological Medicine 18, 331–340.CrossRefGoogle Scholar
Oxenstierna, G., Bergstrand, G., Bjerkenstedt, L., Sedvall, G. & Wik, G. (1984). Evidence of disturbed CSF circulation and brain atrophy in cases of schizophrenic psychoses. British Journal of Psychiatry 144, 654–661.Google Scholar
Pocock, S. J. (1983). Clinical Trials: A Practical Approach, pp. 123–130. Wiley: London.Google Scholar
Reveley, A. M., Reveley, M. A. & Murray, R. M. (1984). Cerebral ventricular enlargement in non-genetic schizophrenia: A controlled twin study. British Journal of Psychiatry 144, 89–93.CrossRefGoogle ScholarPubMed
Schulz, S. C., Sinicope, P., Kishore, P. & Friedel, R. O. (1983). Treatment response and ventricular enlargement in young schizophrenic patients. Psychopharmacological Bulletin 19, 510–512.Google ScholarPubMed
Shur, E. (1982). Family history and schizophrenia: characteristics of groups with and without positive family history. Psychological Medicine 12, 591–594.CrossRefGoogle Scholar
Smith, R. C., Crayton, J. W., Tamminga, C., Dekirmenjian, H., Schoolar, N. C. & Davis, J. M. (1979). Blood levels of neuroleptic drugs, clinical response and plasma prolactin in chronic nonresponding schizophrenic patients. In The Kinetics of Psychiatric Drugs (ed. Schoolar, J. C. and Claghorn, J. L.), pp. 137–170. Brunner/Mazel: New York.Google Scholar
Smith, R. C., Baumgartner, R., Ravichandram, G. K., Mauldin, M., Burd, A., Vroulis, G., Gordon, J. & Calderon, M. (1985). Lateral ventricular enlargement and clinical response in schizophrenia. Psychiatric Research 14, 241–253.CrossRefGoogle ScholarPubMed
Smith, G. N. & Iacono, W. G. (1986). Lateral ventricular size in schizophrenia and choice of control group. Lancet i, 1450.CrossRefGoogle Scholar
Spitzer, R. L., Endicott, J. & Robins, E. (1977). Research Diagnostic Criteria (RDC) for a Selected Group of Functional Disorders, (third edn). New York State Psychiatric Institute: New York.Google Scholar
Spitzer, R. L. & Endicott, J. (1978). Schedule for Affective Disorders and Schizophrenia. New York State Psychiatric Institute: New York.Google Scholar
Statistical Package for Social Sciences (SPSS-X), (1983). McGraw-Hill: New York.Google Scholar
Synek, V. & Reuben, J. R. (1976). The ventricular brain ratio using planimetric measurement of EMI scans. British Journal of Radiology 49, 233–237.CrossRefGoogle ScholarPubMed
Tune, L. E. & Coyle, J. T. (1982). Neuroleptic drug level monitoring in psychiatry: Focus on radioreceptor assay techniques. Therapeutic Drug Monitoring 4, 59–64.CrossRefGoogle ScholarPubMed
Weinberger, D. R., Bigelow, L. B., Kleinman, J. E., Klien, S. T., Rosenblatt, J. E. & Wyatt, R. J. (1980). Cerebral ventricular enlargement in chronic schizophrenia. An association with poor response to treatment. Archives of General Psychiatry 37, 11–13.CrossRefGoogle ScholarPubMed
Weinberger, D. R. (1984). Computed tomography (CT) findings in schizophrenia: speculation on the meaning of it all. Journal of Psychiatric Research 18, 477–490.CrossRefGoogle Scholar
Williams, A. O., Reveley, M. A., Kolakowska, T., Ardern, M. & Madelbrote, B. M. C. (1985). Schizophrenia with good and poor outcome. II. Cerebral ventricular size and its significance. British Journal of Psychiatry 146, 239–246.CrossRefGoogle ScholarPubMed