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Vitamin D status of British African-Caribbean residents: analysis of the UK Biobank cohort

Published online by Cambridge University Press:  08 February 2022

R.M. Vearing ,
K.H. Hart ,
K. Charlton ,
Y. Probst ,
D. Blackbourn ,
K. Ahmadi ,
S.A. Lanham-New  and
A.L Darling
R.M. Vearing
Affiliation:
School of Biosciences and Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK School of Medicine, Faculty of Science Medicine and Health, University of Wollongong, Wollongong, Australia Illawarra Health and Medical Research Institute, Wollongong, Australia
K.H. Hart
Affiliation:
School of Biosciences and Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK
K. Charlton
Affiliation:
School of Medicine, Faculty of Science Medicine and Health, University of Wollongong, Wollongong, Australia Illawarra Health and Medical Research Institute, Wollongong, Australia
Y. Probst
Affiliation:
School of Medicine, Faculty of Science Medicine and Health, University of Wollongong, Wollongong, Australia Illawarra Health and Medical Research Institute, Wollongong, Australia
D. Blackbourn
Affiliation:
School of Biosciences and Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK
K. Ahmadi
Affiliation:
School of Biosciences and Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK
S.A. Lanham-New
Affiliation:
School of Biosciences and Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK
A.L Darling
Affiliation:
School of Biosciences and Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK
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Abstract

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Proceedings of the Nutrition Society , Volume 81 , Issue OCE1: Winter Conference 2021, 7–8 December 2021, Obesity and the brain , 2022 , E36
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Copyright © The Authors 2022

Vitamin D deficiency is a global health issue(Reference Wilson, Tripkovic and Hart1). However, little is known about the vitamin D status of the United Kingdom (UK) African-Caribbean (AC) population, even though this population group is likely at increased risk of vitamin D deficiency, due to latitude and skin type(Reference Wilson, Tripkovic and Hart1,Reference Clemens, Adams and Henderson2) .

This cross-sectional study explored the 25(OH)D concentration and vitamin D intake of AC individuals from the UK Biobank Cohort, who were aged 40 years and over at baseline (2006–2010). For context, the AC population was also compared to the African (AF), South Asian (SA) and White European (WE) subsets of the UK Biobank.

For AC, n = 4046 had a valid 25(OH)D measurement. Of these, n = 1499 (37.0%) were deficient (<25nmol/L), n = 1906 (41.1%) were insufficient (25–50 nmol/L) and n = 642 (15.9%) were sufficient (>50nmol/L). Median (IQR) for 25(OH)D was 30.0 (20.9) nmol/L and median vitamin D intake was 1.6 (2.6) μg/day, with only n = 64 (4.8%) of AC meeting the UK recommended nutrient vitamin D intake of 10μg/day. For the other ethnic groups, the median (IQR) for 25(OH)D concentration was 30.2 (20.0) nmol/L in AF, 20.7 (18.5) nmol/L in SA and 49.2 (29.5) nmol/L in WE. Logistic regression showed that brown/black skin type (OR 1.77, 95% CI 1.19,2.63), winter blood draw (OR 1.22, 95% CI 0.98, 1.51), not consuming oily fish (OR 1.74, 95% CI 1.19, 2.54) and not using vitamin D supplements (OR 2.97, 95% CI 2.50, 3.53) were predictors of increased odds of vitamin D deficiency (<25nmol/L), whilst older age (OR 0.47, 95% 0.37, 0.61) and summer (OR 0.36, 95% CI 0.28, 0.45) or autumn blood draws (OR 0.63, 95% CI 0.51, 0.79) were significantly associated with a reduction in the odds of vitamin D deficiency.

We found high levels of vitamin D deficiency and insufficiency in this AC population. This is of concern due to the individual and societal implications of an increased morbidity. Of note, the UK Biobank participants may be healthier than the national average(Reference Fry, Littlejohns and Sudlow3), meaning these results may be an underestimate of the true degree of vitamin D deficiency in the UK AC population. Public health messaging for this group may need to focus on year-round vitamin D supplementation and increasing intakes of culturally appropriate vitamin D rich foods. These data also lend support to the urgent requirement for a revised vitamin D RNI for ethnic groups.

Acknowledgments

This work is part of the PhD of RM. Vearing, which is funded by the Universities Global Partnership Network, co-supervised by the Universities of Surrey and Wollongong. This research was conducted using the UK Biobank resource under Project 15168. KC, KH and YP did not view the individual participant data.

References

Wilson, LR, Tripkovic, L, Hart, KH et al. (2017)Proc Nutr Soc, 76(3), 392–399.CrossRefGoogle Scholar
Clemens, TL, Adams, JS, Henderson, SL et al. (1982) Lancet, 1(8263), 74–76.CrossRefGoogle Scholar
Fry, A, Littlejohns, TL, Sudlow, C et al. (2017) Am J Epidemiol, 186(9), 1026–1034.CrossRefGoogle Scholar