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Determinants of bone mineral density in postmenopausal women in Northern Ireland

Published online by Cambridge University Press:  19 October 2012

M. M. Slevin ,
P. Allsopp ,
P. J. Magee ,
M. E. Duffy ,
J. M. W. Wallace ,
M. P. Bonham ,
J. J. Strain  and
E. M. McSorley
M. M. Slevin
Affiliation:
Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, BT52 1SA, UK
P. Allsopp
Affiliation:
Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, BT52 1SA, UK
P. J. Magee
Affiliation:
Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, BT52 1SA, UK
M. E. Duffy
Affiliation:
Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, BT52 1SA, UK
J. M. W. Wallace
Affiliation:
Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, BT52 1SA, UK
M. P. Bonham
Affiliation:
Department of Nutrition and Dietetics, Monash University, Faculty of Medicine, Nursing and Health Sciences, 246 Clayton Road, Clayton, VIC 3168Australia
J. J. Strain
Affiliation:
Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, BT52 1SA, UK
E. M. McSorley
Affiliation:
Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, BT52 1SA, UK
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Abstract

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Abstract
Information
Proceedings of the Nutrition Society , Volume 71 , Issue OCE2: Summer Meeting hosted by the Irish Section, 16–19 July 2012, Translational nutrition: integrating research, practice and policy , 2012 , E150
Copyright
Copyright © The Authors 2012

Postmenopausal osteoporosis is a chronic disease characterized by decreased bone mass, increased bone turnover and increased fracture risk( Reference Massé, Dosy and Tranchant 1 ). Bone mineral density (BMD) is routinely used as the gold standard determinant of fracture risk and ultimately osteoporosis( 2 ). Numerous risk factors, including age, body composition, lifestyle factors and bone turnover markers (BTM), which impact on BMD have been identified. Nevertheless, there is conflicting evidence with regard to certain determinants, in particular, BTM( Reference Civitelli, Armamento-Villareal and Napoli 3 ) and body composition( Reference Ho-Pham, Nguyen and Lai 4 ) of BMD in postmenopausal women. The aim of this study therefore, was to assess BMD in Northern Irish postmenopausal women and to examine potential determinants of BMD.

Non-osteoporotic postmenopausal women (N=300) (45–75 years) were recruited between October 2008 and June 2009, as part of a larger intervention study (REC/08/0083). Total body T-score and body composition were measured using a dual energy x-ray absorptiometry (DEXA) scan. Osteocalcin, deoxypyridinoline crosslinks, C-terminal crosslaps, 25-hydroxy vitamin D and parathyroid hormone (PTH) were measured. Dietary calcium intake and lifestyle factors were determined by questionnaire. Multiple linear regression was performed to identify independent predictors of BMD. Model 1 included age, body mass index (BMI), percent fat (FM) and fat free mass (FFM); model 2 encompassed the variables from model 1 in addition to; number of years postmenopausal, parity, smoking status, statin use, vitamin D status, PTH status and dietary calcium intake; and model 3 included all of the above variables in addition to BTM.

Model 1 explained 37% of the variance in total body T-score, F (4, 253)=39.43, p<0.001. Model 2 explained a further 3% of the variance, F (11, 246)=16.28, p<0.001. Model 3 explained a further 1% of the variance, F (15, 242)=13.00, p<0.001. The main variables which explained most of the variance in total body T score were increasing age, which was associated with lower BMD (β=−0.26; p=0.001), higher percentage body fat, which was associated with higher BMD (β=0.225; p=0.048), higher fat free mass (FFM), which was associated with higher BMD (β=0.385; p<0.001) and current smoking which was negatively associated with BMD (β=−0.163; p=0.001).

Within this cohort, BTM did not explain any of the variance in BMD, albeit the obvious risk factors of increasing age and smoking were associated with a lower total body BMD, whereas weight (FM and FFM) were associated with a higher BMD. Similar findings have been reported recently by others( Reference Ho-Pham, Nguyen and Lai 4 , Reference Park, Song and Sung 5 ). In conclusion, findings from this study indicate that there is a relationship between FFM and BMD, suggesting that muscle weight has an additional predictive value over fat mass and, together with exercise, may potentially help to prevent osteoporosis.

References

1. Massé, PG, Dosy, J, Tranchant, CC et al. (2004) J Hum Nutr Dietet 17, 121–132.CrossRefGoogle Scholar
2. World Health Organisation (1994) Technical Report Series 843. Geneva: WHO.Google Scholar
3. Civitelli, R, Armamento-Villareal, R & Napoli, N (2009) Osteoporos Int 20, 843–851.CrossRefGoogle Scholar
4. Ho-Pham, LT, Nguyen, ND, Lai, TQ et al. (2010) BMC Musculoskeletal Disorders 11, 59.CrossRefGoogle Scholar
5. Park, JH, Song, YM, Sung, J et al. (2012) Bone 50(4): 1006–1011.CrossRefGoogle ScholarPubMed