In this proceeding, we summarize the key science goals and reference design for a next-generation Very Large Array (ngVLA) that is envisaged to operate in the 2030s. The ngVLA is an interferometric array with more than 10 times the sensitivity and spatial resolution of the current VLA and ALMA, that will operate at frequencies spanning ~1.2 – 116 GHz, thus lending itself to be highly complementary to ALMA and the SKA1. As such, the ngVLA will tackle a broad range of outstanding questions in modern astronomy by simultaneously delivering the capability to: unveil the formation of Solar System analogues; probe the initial conditions for planetary systems and life with astrochemistry; characterize the assembly, structure, and evolution of galaxies from the first billion years to the present; use pulsars in the Galactic center as fundamental tests of gravity; and understand the formation and evolution of stellar and supermassive blackholes in the era of multi-messenger astronomy.