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Investigating the effect of PrP genotype on production traits in Charollais sheep

Published online by Cambridge University Press:  23 November 2017

RC Moore ,
K Boulton  and
S C Bishop
RC Moore*
Affiliation:
Roslin Institute, Edinburgh, United Kingdom
K Boulton
Affiliation:
Meat and Livestock Commission, Milton Keynes, United Kingdom
S C Bishop
Affiliation:
Roslin Institute, Edinburgh, United Kingdom
*
Email: [email protected]
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Extract

Prion protein (PrP) genotype controls susceptibility to scrapie in sheep (Baylis, 2005) and a number of other transmissible spongiform encephalopathies including Creutzfeldt-Jakob disease in humans. Sheep have five PrP alleles (ARQ, ARH, AHQ, VRQ and ARR) and up to 15 PrP genotypes. In an attempt to control and eventually eradicate scrapie the GB National Scrapie Program (NSP, 2004) promotes the use of rams with scrapie resistant PrP genotypes (e.g. ARR/ARR) and discourages the use of scrapie susceptible genotypes (e.g VRQ carriers). Little is known about the effects of PrP genotype on sheep biology in general and commercially relevant production traits in particular. This study aims to determine whether PrP genotype is associated with production traits in a number of UK commercial sheep breeds, and results are reported here for the Charollais breed.

Type
Theatre presentations
Information
Proceedings of the British Society of Animal Science , Volume 2006 , March 2006 , pp. 1
Copyright
Copyright © The American Society of International Law 2016

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References

Baylis, M., Chihota, C., Stevenson, E., Goldmann, W., Smith, A., Sivam, K., Tongue, S. and Gravenor, M. B. 2004. Risk of scrapie in British sheep of different prion protein genotype. Journal of General Virology 85: 2735–2740.Google Scholar
Gilmour, A. R., Gogel, B. J., Cullis, B. R., Welham, S. J. and Thompson, R. 2002. ASReml User Guide Release 1.0. VSN International Ltd, Hemel Hempstead, UK. NSP, 2004 http://www.defra.gov.uk/animalh/bse/othertses/scrapie/nsp/index.html Google Scholar