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Effect of growth hormone on non insulin mediated glucose uptake in sheep
Published online by Cambridge University Press: 05 November 2021
Extract
Glucose uptake by tissues is controlled by both insulin dependent and insulin independent pathways. One mechanism by which growth hormone is thought to increase the productive efficiency of ruminants is to antagonise insulin mediated glucose uptake (IMGU), thereby sparing glucose for non insulin mediated glucose uptake (NIMGU) dependent processes, such as milk production and growth (Rose and Obara, 1996). The aim of this experiment was to determine if growth hormone also has an effect on whole body NIMGU, by infusing somatostatin. Somatostatin prevents the release of insulin from the pancreas, thus, once insulin has cleared from the circulation, estimates of glucose turnover should be entirely non insulin mediated (Baron et al. 1987).
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- Copyright © British Society of Animal Science 1997