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Synthesis and Characterization of Magnetic Polymeric Nanospheres for Biomedical Applications

Published online by Cambridge University Press:  11 February 2011

D. K. Kim ,
M. Mikhaylova ,
M. Toprak ,
A. Guyou ,
Y. K. Jeong  and
M. Muhammed
D. K. Kim
Affiliation:
Materials Chemistry Division, Royal Institute of Technology, SE-100 44 Stockholm, Sweden
M. Mikhaylova
Affiliation:
Materials Chemistry Division, Royal Institute of Technology, SE-100 44 Stockholm, Sweden
M. Toprak
Affiliation:
Materials Chemistry Division, Royal Institute of Technology, SE-100 44 Stockholm, Sweden
A. Guyou
Affiliation:
Institut des Science et Techniques de Grenoble, France
Y. K. Jeong
Affiliation:
KICET (Korea Institute of Ceramic Engineering and Technology) 153–801, Seoul, Korea
M. Muhammed
Affiliation:
Materials Chemistry Division, Royal Institute of Technology, SE-100 44 Stockholm, Sweden
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Abstract

Entrapment of proteins in biodegradable nanospheres has been widely investigated as a technique to produce sustained release formulations for protein or anti-cancer drugs administration. Amphiphilic PLLA-mPEG diblock copolymer was prepared by ring opening polymerization (ROP) to form polymeric nanoparticles with a core-shell structure. The main encapsulation technique done is a water-in-oil-in-water (w/o/w) solvent evaporation technique. Here, protein was encapsulated using a newly developed water-in-oil emulsion-solvent diffusion technique. This technique leads to the formation of an emulsion combined with the immediate precipitation of the PLLA-mPEG. This phenomenon is caused by the diffusion of the polymer solvent to an external organic phase.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 750: Symposium Y – Surface Engineering 2002–Synthesis, Characterization and Applications , 2002 , Y9.2
Copyright
Copyright © Materials Research Society 2003

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References

REFERENCE

Harris, J., J. Macromol. Sci.-Rev. Macromol. Chem. Phys. C 25, 325 (1985)Google Scholar
Gref, R., Luck, M., Quellec, P., Marchand, M., Dellacherie, E., Harnisch, S., blunk, T., Müller, R. H., Colloids and Surfaces B: Biointerfaces 18, 301 (2000)Google Scholar
Quellec, P., Gref, R., Perrin, L., Dellacherie, E., Sommer, F., Verbavatz, J. M., Alonso, M. J., John Wiley & Sons, Inc. (1998).Google Scholar
Bazile, D., prud'homme, C., Bassoullet, M. T., Marlard, M., Spenlehauer, G., and Veillard, M., J. Pharm. Sci. 84, 493 (1995)Google Scholar
Södergård, A., Stolt, M., Prog. Polym. Sci. 27, 1123 (2002)Google Scholar
Kricheldorf, H. R., Kreiser-Saunders, I., Boettcher, C., Polymer 36, 1253 (1995)Google Scholar
Gruvegård, M., Lindberg, T., Albertsson, A-C., J. Macromo.l Sci. Chem. A 35, 885 (1998)Google Scholar
Kim, S. Y., Shin, I. G., Lee, Y. M., J. Control. Release 565, 197 (1998)Google Scholar