Hostname: page-component-78c5997874-4rdpn Total loading time: 0 Render date: 2024-11-05T11:21:07.968Z Has data issue: false hasContentIssue false
  • English
  • Français

Peptide Nucleic Acid (PNA). a Structural DNA Mimic

Published online by Cambridge University Press:  15 February 2011

Peter E. Nielsen
Peter E. Nielsen*
Affiliation:
Research Center for Medical Biotechnology, Department of Medical Biochemistry & Genetics, Biochemistry Laboratory B, The Panum Institute, University of Copenhagen, Blegdarnsvej 3c, DK 2200 Copenhagen N, Denmark.
Get access

Extract

Deoxyribonucleic acid (DNA) may be regarded as the central molecule of life since it is the carrier of genetic information; it is the chemical constituent of the genes. DNA is a biopolymer composed of deoxyribonucleoside units connected via phosphodiester bridges (Figure 1a). It is the linear order of the nucleobases (A, C, G & T) that contain the genetic information, whereas the deoxyribose phosphate backbone primarily fulfils a structural role.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 330: Symposium S – Biomolecular Materials by Design , 1993 , 3
Copyright
Copyright © Materials Research Society 1994

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

1. Helene, C. & Toulme, J.-J.(1990). Biochim. Biophys. Acta, 1049, 99–125.CrossRefGoogle Scholar
2. Crook, S.T. (1992). Curr. Opinion Biotechn. 3, 656–661.Google Scholar
3. Helene, C. (1993).Curr. Opinion Biotechn. 4, 29–36.CrossRefGoogle Scholar
4. Uhlman, E. & Peyman, A. (1990). Chem. Rev. 90, 544–584.Google Scholar
5. Milligan, J.F., Matteucci, M.D. & Martin, J. C. J. Med. Chemistry 36, 1924–1937.Google Scholar
6. Nielsen, P.E., Egholm, M., Berg, R & Buchardt, O.(1991) Science 254, 1497.CrossRefGoogle Scholar
7. Egholm, M., Buchardt, O., Nielsen, P.E. & Berg, R. (1992) J. Amer. Chem. Soc. 114, 1895.Google Scholar
8. Egholm, M., Buchardt, O., Nielsen, P.E. & Berg, R. (1992) J. Amer. Chem. Soc. 115, 9676.Google Scholar
9. Nielsen, P.E., Egholm., M., Berg, R.H. & Buchardt, O. (1993). In “Antisense Research and Application” Crook, S. & Lebleu, B. (eds.).CRC Press, Boca Raton, pp 363–373.Google Scholar
10. Egholm, M, Buchardt, O, Christensen, L, Behrens, C, Freier, S. M. Driver, D.A., Berg, R.H., Kim, S.K., Norden, B. & Nielsen, P.E. (1993) Nature 365, 566–568.Google Scholar
11. Cherny, D. Belotserkovskii, Frank-Kamenetskii, M., Egholm, M., Buchardt, O., Berg, R. & Nielsen, P.E. (1993) Proc. Nati. Acad. Sci. USA. 90, 1667.CrossRefGoogle Scholar
12. Nielsen, P.E., Egholm, E. and Buchardt, O. J. Mol. Recognition (in press).Google Scholar
13. Nielsen, P.E., Egholm, M, Berg, R. & Buchardt, O.(1993) Nucl. Acids Res. 21, 197.Google Scholar
14. Nielsen, P.E., Egholm, M., Berg, R. & Buchardt, O.(1993) Anti Cancer Drug Design. 8, 53.Google Scholar
15. Egholm, M., Behrens, K., Christensen, L., Berg, R., Nielsen, P.E. & Buchardt, O.(1993) J. Chem. Soc. Chem. Commun. 800.Google Scholar
16. Kim, S.K., Nielsen, P.E., Egholm, M., Buchardt, O., Berg, R.H. & Nordn, B. (1993) J. Amer. Chem. Soc. 115, 6477–6481.Google Scholar
17. Demidov, V., Frank-Kamenetskii, M., Egholm, M., Buchardt, O. & Nielsen, P.E. (1993) Nucl. Acids Res. 21, 2103.Google Scholar
18. Oerum, H., Egholm, M., Berg, R.H., Buchardt, O., Stanley, C. and Nielsen, P.E.Nucleic Acids Res. (in press).Google Scholar
19. Hyrup, B., Egholm, M., Rolland, M., Nielsen, P.E., Berg, R. & Buchardt, O. (1993) J. Chem. Soc. Chem. Commun. 518.Google Scholar
20. Nielsen, P. E.(1993) Antiviral News 1, 37.Google Scholar
21. Hanvey, J.C.; Peffer, N.C.; Bisi, J.E.; Thomson, S.A.; Cadilla, R; Josey, J.A.; Ricca, D.J., Hassman, C.F.; Bonham, M.A.; Au, K.G.; Carter, S.G.; Bruckenstein, D.A.; Boyd, A:L.; Noble, S.A. & Babiss, L.E.(1992) Science 258 1481–1485.Google Scholar
22. Nielsen, P.E. (1993) Origin of Life (in press).Google Scholar